Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about APH-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | APH |
| Protein Family | APH-1 family (γ-secretase complex) |
| Function | Anterior Pharynx Defective 1 (APH-1) is a conserved multipass transmembrane protein that serves as an essential stoichiometric component of the γ-secretase complex[@goutte2002] |
| Subcellular Localization | Endoplasmic reticulum, Golgi apparatus, plasma membrane |
| UniProt ID | Q9WVM4 (APH-1A), Q8WW43 (APH-1B) |
| GeneCards | APH |
| Human Protein Atlas | APH |
| Interactions | NICASTRIN, PRESENILIN, PEN-2 |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
APH_1(["APH-1"])
NICASTRIN["NICASTRIN"]
PRESENILIN(["PRESENILIN"])
PEN_2(["PEN-2"])
NICASTRIN -->|"interacts with"| APH_1
PRESENILIN -->|"interacts with"| APH_1
PEN_2 -->|"interacts with"| APH_1
style APH_1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style NICASTRIN fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style PRESENILIN fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
style PEN_2 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| NICASTRIN | interacts_with | gene | 0.50 |
| PRESENILIN | interacts_with | protein | 0.50 |
| PEN-2 | interacts_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||