Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PEN-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PEN |
| Function | Pen 2 Protein Gamma Secretase Subunit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role ... |
| GeneCards | PEN |
| Human Protein Atlas | PEN |
| Interactions | APH-1, NICASTRIN, PRESENILIN |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PEN_2["PEN-2"]
APH_1["APH-1"]
PEN_2 -->|"interacts with"| APH_1
NICASTRIN["NICASTRIN"]
NICASTRIN -->|"interacts with"| PEN_2
PRESENILIN["PRESENILIN"]
PRESENILIN -->|"interacts with"| PEN_2
style PEN_2 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| APH-1 | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NICASTRIN | interacts_with | gene | 0.50 |
| PRESENILIN | interacts_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||