| Gene Symbol | APH1A, APH1B |
| Full Name | APH1A |
| Aliases | APH1, aph1 |
| Protein Family | APH-1 family (γ-secretase complex) |
| Protein Type | Gene |
| Function | Complex Formation Initiation: APH-1 binds to presenilin in the ER, initiating complex assembly |
| Primary Expression | Endoplasmic reticulum, Golgi apparatus, plasma membrane |
| Subcellular Localization | Endoplasmic reticulum, Golgi apparatus, plasma membrane |
| Molecular Weight | 35 kDa |
| Amino Acids | 346 aa |
| UniProt ID | Q9WVM4 |
| Gene | APH1A, APH1B |
| PDB | 5A63, 6IDF |
| Mol. Weight | ~35 kDa (APH-1A: 346 aa, APH-1B: 350 aa) |
| Associated Diseases | Alzheimer's Disease, Frontotemporal Dementia |
| Interactions | NCT, PSEN, PSEN1, Gamma-Secretase Complex, ALZHEIMER'S DISEASE, NEURON |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |