protein

ARRB1 PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARRB1 PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Arrestin beta 1 (ARRB1) - versatile scaffolding protein regulating GPCR signaling, clathrin-mediated endocytosis, and neurodegeneration in Alzheimer's and Parkinson's disease

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🔬 Protein Info

Gene Symbol	ARRB1
Full Name	Arrestin Beta 1
Chromosome	11q13.1
Function	is a member of the arrestin family of proteins that plays a crucial role in regulating G protein-coupled receptor (GPCR) signaling [1](https://pubmed.
Molecular Weight	46 kDa
Amino Acids	418 aa
Pathways	MAPK pathway, PI3K, NF-κB signaling
GeneCards	ARRB1
Human Protein Atlas	ARRB1
Associated Diseases	Cancer
Interactions	AUTOPHAGY, RAB27A, SAMD4
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    A["Gene expression"] --> B["ARRB1 PROTEIN"]
    B --> C["Protein folding and
quality control"]
    B --> D["Cellular signaling"]
    C --> E["Proteostasis"]
    D --> F["Neurotoxicity"]
    E --> G["Disease outcome"]
    F --> G
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class B protein
    class G disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ARRB1 PROTEIN in their description or question text

No additional research found