Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP1B2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATP1B2 encodes the beta-2 subunit of Na+/K+-ATPase, critical for neuronal potassium buffering, astrocyte function, and implicated in glaucoma and neurodegenerative diseases.
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| Gene Symbol | ATP1B2 |
| Full Name | ATPase Na+/K+ Transporting Subunit Beta 2 |
| Chromosome | 17p13.1 |
| Primary Expression | the nervous system, where it plays essential roles in neuronal potassium buffering, astrocyte function, synaptic plasticity, and cellular calcium home |
| Molecular Weight | 33 kDa |
| Gene Type | Protein-coding |
| UniProt ID | P14415 |
| NCBI Gene ID | 481 |
| Ensembl ID | ENSG00000129226 |
| OMIM | 182360 |
| GeneCards | ATP1B2 |
| Human Protein Atlas | ATP1B2 |
| N-terminal transmembrane domain | Single-span transmembrane helix that anchors the protein in the plasma membrane |
| Extracellular domain | Large extracellular region that interacts with the alpha subunit and mediates pump assembly |
| Intracellular domain | Cytoplasmic domain involved in regulatory functions |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATP1B2["ATP1B2
(Na+/K+-ATPase beta2 subunit)"]
NaKATPase["Na+/K+-ATPase
Complex"]
IonGradient["Na+/K+ Ion
Gradient"]
MemPotential["Membrane
Potential"]
NeuronExcite["Neuronal
Excitability"]
CaHomeostasis["Calcium
Homeostasis"]
EnergyMet["Energy
Metabolism"]
OxStress["Oxidative
Stress"]
Inflammation["Neuroinflammation"]
ProteinMisfold["Protein
Misfolding"]
CellDeath["Neuronal
Cell Death"]
Neurodegeneration["Neurodegeneration"]
AD["Alzheimer's
Disease"]
PD["Parkinson's
Disease"]
ATP1B2 -->|"assembles with"| NaKATPase
NaKATPase -->|"maintains"| IonGradient
IonGradient -->|"regulates"| MemPotential
MemPotential -->|"controls"| NeuronExcite
IonGradient -->|"regulates"| CaHomeostasis
NaKATPase -->|"requires"| EnergyMet
EnergyMet -->|"when impaired"| OxStress
OxStress -->|"triggers"| Inflammation
Inflammation -->|"promotes"| ProteinMisfold
ProteinMisfold -->|"leads to"| CellDeath
CellDeath -->|"causes"| Neurodegeneration
Neurodegeneration -->|"manifests as"| AD
Neurodegeneration -->|"manifests as"| PD
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff
class ATP1B2 central
class NaKATPase,IonGradient,MemPotential,CaHomeostasis protective
class OxStress,Inflammation,ProteinMisfold,CellDeath,Neurodegeneration pathological
class NeuronExcite,EnergyMet regulatory
class AD,PD disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATP1B2 in their description or question text
No additional research found