ATP2A1

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP2A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ATP2A1 Gene

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graph TD
    ATP2A1["ATP2A1 (SERCA1)"]
    Ca_pump["Calcium pump activity"]
    ER_Ca["ER calcium storage"]
    Cytosolic_Ca["Cytosolic calcium levels"]
    Ca_homeostasis["Calcium homeostasis"]
    ER_stress["ER stress"]
    UPR["Unfolded protein response"]
    Mitochondria["Mitochondrial dysfunction"]
    ROS["Reactive oxygen species"]
    Neurodegeneration["Neurodegeneration"]
    Neuron_death["Neuronal cell death"]
    Protein_misfolding["Protein misfolding"]
    ATP_depletion["ATP depletion"]
    
    ATP2A1 -->|"encodes"| Ca_pump
    Ca_pump -->|"maintains"| ER_Ca
    Ca_pump -->|"reduces"| Cytosolic_Ca
    ER_Ca -->|"supports"| Ca_homeostasis
    Cytosolic_Ca -->|"disrupts"| Ca_homeostasis
    Ca_homeostasis -->|"loss leads to"| ER_stress
    ER_stress -->|"activates"| UPR
    ER_stress -->|"triggers"| Protein_misfolding
    UPR -->|"chronic activation"| Neuron_death
    Protein_misfolding -->|"causes"| Mitochondria
    Mitochondria -->|"produces"| ROS
    Mitochondria -->|"causes"| ATP_depletion
    ROS -->|"promotes"| Neurodegeneration
    Neuron_death -->|"contributes to"| Neurodegeneration
    
    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    
    class ATP2A1,Ca_pump central
    class ER_Ca,Ca_homeostasis protective
    class ER_stress,UPR,ROS,Protein_misfolding,Mitochondria,ATP_depletion,Cytosolic_Ca,Neuron_death pathological
    class Neurodegeneration disease