concept

INSR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	INSR
Key Genes/Proteins	Insulin receptor
Related Diseases	ALZHEIMER, Ms, Cancer, Tumor, Pancreatic Cancer

Wiki Pages (12)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INSR["INSR"]
    INSR -->|"encodes"| Insulin_receptor["Insulin receptor"]
    INSR -->|"interacts"| Ms["Ms"]
    INSR -->|"interacts"| Cancer["Cancer"]
    INSR -->|"interacts"| Tumor["Tumor"]
    INSR -->|"inhibits"| Pancreatic_Cancer["Pancreatic Cancer"]
    INSR -->|"inhibits"| Diabetes["Diabetes"]
    INSR -->|"inhibits"| Inflammation["Inflammation"]
    INSR -->|"inhibits"| Obesity["Obesity"]
    IGF1["IGF1"] -->|"regulates"| INSR
    IGF1R["IGF1R"] -->|"regulates"| INSR
    PI3K["PI3K"] -->|"interacts"| INSR
    PIK3CA["PIK3CA"] -->|"interacts"| INSR
    MMP9["MMP9"] -->|"target for"| INSR
    PPARA["PPARA"] -->|"target for"| INSR
    RELA["RELA"] -->|"interacts"| INSR
    AKT1["AKT1"] -->|"target for"| INSR
    INFLAMMATION["INFLAMMATION"] -->|"inhibits"| INSR

Outgoing (80)

Target	Relation	Type	Str
Insulin receptor	encodes	protein	0.70
ALZHEIMER	associated_with	disease	0.70
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Pancreatic Cancer	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Type 2 Diabetes	inhibits	disease	0.65
Type 2 Diabetes	expressed_in	disease	0.65
Insulin Resistance	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Alzheimer	protects_against	disease	0.65
Als	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Aging	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
PI3K	regulates	gene	0.65
PI3K	protects_against	gene	0.65
PI3K	targets	gene	0.65
PI3K	treats	gene	0.65
CANCER	interacts_with	gene	0.60
Mapk	interacts_with	pathway	0.60
Pi3K	interacts_with	pathway	0.60
TTR	interacts_with	gene	0.60
PPARG	therapeutic_target	gene	0.60
ESR1	interacts_with	gene	0.60
MMP2	interacts_with	gene	0.60
SLC2A1	interacts_with	gene	0.60
Akt	therapeutic_target	pathway	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
INSULIN RESISTANCE	expressed_in	gene	0.60
EXERCISE	expressed_in	gene	0.60
PI3K	inhibits	gene	0.60
BDNF	expressed_in	gene	0.60
RAS	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
AKT	inhibits	gene	0.60
EXOSOMES	expressed_in	gene	0.60
Mapk	inhibits	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
NGF	activates	gene	0.60
ROS	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60

Incoming (41)

Source	Relation	Type	Str
NGF	targets	gene	0.65
IGF1	regulates	gene	0.60
IGF1R	regulates	gene	0.60
PI3K	interacts_with	gene	0.60
PIK3CA	interacts_with	gene	0.60
MMP9	therapeutic_target	gene	0.60
PPARA	therapeutic_target	gene	0.60
IGF1R	therapeutic_target	gene	0.60
RELA	interacts_with	gene	0.60
AKT1	therapeutic_target	gene	0.60
KRAS	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
OVERVIEW	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
GASTRODIN	activates	gene	0.60
AKT	activates	gene	0.60
ALZHEIMER	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
NGF	activates	gene	0.60
ROS	protects_against	gene	0.60
AND	activates	gene	0.60
DEMENTIA	expressed_in	gene	0.60
AKT	co_discussed	gene	0.60
ADH1B	regulates	gene	0.60
APOE	regulates	gene	0.60
FTO	regulates	gene	0.60
ABCB1	activates	gene	0.60
APOD	activates	gene	0.60
COL4A1	activates	gene	0.60
AQP5	biomarker_for	gene	0.60
CLCN1	causes	gene	0.55
DMPK	causes	gene	0.55
ATP2A1	protects_against	gene	0.55
CLCN1	protects_against	gene	0.55
Pi3K	activates	pathway	0.50
Pi3K/Akt	activates	pathway	0.50
OBESITY	associated_with	disease	0.50
NAFLD	associated_with	disease	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

INSR

Understanding Entity Pages

Wiki Pages (12)

Blood-Brain Barrier

Myotonic Dystrophy

PTPRF Protein

metabolic-syndrome-parkinsons-axis

AKT1 Protein (Protein Kinase B Alpha)

Continuous Glucose Monitoring for Parkinson's Disease

AgRP/NPY Neurons

Insulin Receptor (INSR) Neurons

IRS-1 (Insulin Receptor Substrate 1)

ATP2A1 Gene