Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AUTOPHAGY_LYSOSOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| alpha_synuclein | degrades | protein | 0.90 |
| AUTOPHAGY_PATHWAY | activates | pathway | 0.72 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SCHAFTOSIDE | regulates | drug | 0.72 |
| CAMKII_DELTA | regulates | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| C9ORF72 autophagy-lysosome collapse across ALS and FTD | 0.816 | multi | Cross-disease neurodegeneration mechanis |
| Transcriptional Autophagy-Lysosome Coupling | 0.777 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| TFEB Nuclear Translocation Clears α-Synuclein via Autophagy- | 0.580 | neurodegeneration | Test Preregistration Analysis |
| HBOT (2.0 ATA, 60 min) activates TFEB-mediated autophagy-lys | 0.560 | neurodegeneration | What are the optimal oxygen pressure, du |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Autophagy Enhancement Drug Screening for Neurodegeneration | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Macroautophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Validate Mitochondria-Lysosome Contact Site Dysfunction in PD | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| MLCS Quantification in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammati [PMID:37678798] | Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang | Cell Mol Gastroenterol Hepatol | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and inv [PMID:35176466] | Zhang L, Liang B, Xu H, Gong Y, Hu W, Ji | J Ethnopharmacol | 2022 | 1 |
| Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892] | Wang Y, An H, Liu T, Qin C, Sesaki H, Gu | Cell Rep | 2019 | 1 |
| AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310] | Song X, Zhu S, Chen P, Hou W, Wen Q, Liu | Curr Biol | 2018 | 1 |
| Obestatin controls the ubiquitin-proteasome and autophagy-lysosome systems in gl [PMID:28675664] | Cid-Díaz T, Santos-Zas I, González-Sánch | J Cachexia Sarcopenia Muscle | 2017 | 1 |
| PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum [PMID:41920736] | Wang Z, Jin N, Li X, Ma X, Feng Y, Yin K | Cell reports | 2026 | 0 |
| Mammalian lipophagy: process and function. [PMID:41681129] | Zhao R, Dai E, Kang R, Liu J, Klionsky D | Autophagy | 2026 | 0 |
| TAZ alleviates ischemic stroke injury by activating Foxo1: Usp1-mediated deubiqu [PMID:41921828] | ["Xin Y", "Sun Y", "Pan E", "Li M", "Che | Free radical biology & medicin | 2026 | 0 |
| Combining network pharmacology and multi-omics reveals the role of Shengdihuang- [PMID:41655545] | Cao X, Shang Y, Qu M, Kang Q, Xu Y et al | Phytomedicine | 2026 | 0 |
| Comparative transcriptomics of adherent and suspension chicken fibroblast cell l [PMID:41763754] | Contreras EJ, Nagarajan A, Bromberg BH, | Food Res Int | 2026 | 0 |
| FOXO1 transcription factor modulates airway epithelial responses to viral infect [PMID:41931532] | Daniel NM, Mann-Nüttel R, Shrestha Palik | PLoS One | 2026 | 0 |
| Effects of Vitamin A Restriction on Carcass Characteristics, Antioxidant Capacit [PMID:41856090] | Zhang X, Zhang C, Song J, Bai J, Hao B, | Animal bioscience | 2026 | 0 |
| Transcriptomic identification of CREB1 and FOXO1 activation in neuregulin-1-medi [PMID:41907189] | Bennett KR, Surles-Zeigler MC, Augello C | Frontiers in molecular neurosc | 2026 | 0 |
| Human MKP-3 isoforms display differential structural and functional profiles. [PMID:41865406] | Mori Sequeiros Garcia MM, Nudler S, Bigi | Biochemical and biophysical re | 2026 | 0 |
| Role of Uncertainty in Illness and Coping Strategies in Advance Directive Comple [PMID:38567890] | ["Fuson O", "Mitra A", "Little C", "Hiat | Journal of clinical gastroente | 2025 | 0 |
| The GLP-1 agonist semaglutide ameliorates cognitive regression in P301S tauopath [PMID:39875022] | ["Elbadawy N", "Saad M", "Elfarrash S", | European journal of pharmacolo | 2025 | 0 |
| The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] | Dai L, Wang J, Meng L, Zhang X, Xiao T, | PLoS biology | 2025 | 0 |
| The multifaceted impact of physical exercise on FoxO signaling pathways. [PMID:40861274] | Liu W, Meng P, Li Z, Shen Y, Meng X, Jin | Frontiers in cell and developm | 2025 | 0 |
| Programmable protein stabilization with language model-derived peptide guides. [PMID:40229275] | ["Hong L", "Ye T", "Wang T", "Srijay D", | Nature communications | 2025 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning AUTOPHAGY_LYSOSOME in their description or question text
No additional research found