Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALPHA_SYNUCLEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALPHA_SYNUCLEIN |
| Key Genes/Proteins | SNCA, BAG3, PLK2_PROTEIN, BMAL1, CNTNAP4 |
| Related Diseases | PARKINSONS_DISEASE, PARKINSON_DISEASE, COGNITIVE_FUNCTION, NEURODEGENERATION |
| Related Pathways | CA2_HOMEOSTASIS |
Knowledge base pages for this entity
graph TD
ALPHA_SYNUCLEIN["ALPHA_SYNUCLEIN"]
ALPHA_SYNUCLEIN -->|"causes"| PD["PD"]
ALPHA_SYNUCLEIN -->|"causes"| DLBD["DLBD"]
ALPHA_SYNUCLEIN -->|"causes"| MSA["MSA"]
ALPHA_SYNUCLEIN -->|"contributes to"| lewy_bodies["lewy_bodies"]
ALPHA_SYNUCLEIN -->|"causes"| DOPAMINERGIC_NEURONS["DOPAMINERGIC_NEURONS"]
ALPHA_SYNUCLEIN -->|"regulates"| COGNITIVE_FUNCTION["COGNITIVE_FUNCTION"]
ALPHA_SYNUCLEIN -->|"activates"| CD4_T_CELLS["CD4_T_CELLS"]
ALPHA_SYNUCLEIN -->|"activates"| ASTROCYTES["ASTROCYTES"]
SNCA["SNCA"] -->|"encodes"| ALPHA_SYNUCLEIN
ASO["ASO"] -->|"inhibits"| ALPHA_SYNUCLEIN
BAG3["BAG3"] -->|"inhibits"| ALPHA_SYNUCLEIN
PLK2_PROTEIN["PLK2_PROTEIN"] -->|"regulates"| ALPHA_SYNUCLEIN
BMAL1["BMAL1"] -->|"activates"| ALPHA_SYNUCLEIN
CNTNAP4["CNTNAP4"] -->|"regulates"| ALPHA_SYNUCLEIN
CEFTRIAXONE["CEFTRIAXONE"] -->|"inhibits"| ALPHA_SYNUCLEIN| Target | Relation | Type | Str |
|---|---|---|---|
| PARKINSONS_DISEASE | associated_with | disease | 0.87 |
| PARKINSON_DISEASE | associated_with | disease | 0.72 |
| DOPAMINERGIC_NEURONS | causes | cell_type | 0.64 |
| COGNITIVE_FUNCTION | regulates | phenotype | 0.64 |
| CD4_T_CELLS | activates | cell_type | 0.64 |
| ASTROCYTES | activates | cell_type | 0.64 |
| NEURODEGENERATION | causes | phenotype | 0.64 |
| CA2_HOMEOSTASIS | inhibits | pathway | 0.64 |
| INNATE_IMMUNITY | activates | pathway | 0.56 |
| ADAPTIVE_IMMUNITY | activates | pathway | 0.56 |
| MHCII | activates | protein | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SNCA | encodes | gene | 1.00 |
| ASO | inhibits | drug | 0.87 |
| BAG3 | inhibits | protein | 0.72 |
| PLK2_PROTEIN | regulates | protein | 0.72 |
| BMAL1 | activates | protein | 0.64 |
| CNTNAP4 | regulates | gene | 0.64 |
| CEFTRIAXONE | inhibits | drug | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.599 | neurodegeneration | What are the mechanisms by which gut mic |
| H7: Enteric Nervous System Alpha-Synuclein Propagation Block | 0.595 | neurodegeneration | How does engineered C. butyricum cross t |
| Neuronal Subtype-Specific Alpha-Synuclein Expression Normali | 0.382 | neurodegeneration | Which cell types show the most significa |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Meta-analysis of mRNA dysregulation associated with Parkinson's disease and othe [PMID:41183391] | Lin Aung T, Aung YW, Shi X | Biomed Phys Eng Express | 2026 | 1 |
| A human striatal-midbrain assembloid model of alpha-synuclein propagation. [PMID:40919647] | Tran HD, Shin MK, Yeo XY, Jung S, Junaid | Brain | 2026 | 0 |
| Neuronal titration of Snca via enhancer disruption mitigates disease onset in a [PMID:41496593] | Boyd RJ, Kho AR, McClymont SA, Loftus SK | Brain | 2026 | 0 |
| Perampanel Blocks Transsynaptic α-Synuclein Propagation and Neurodegeneration in [PMID:41508763] | Ueda J, Uemura N, Chang J, Hirato T, Ish | Mov Disord | 2026 | 0 |
| Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 p [PMID:41574889] | Fraser KB, Mirelman A, Mabrouk OS, Omer | J Parkinsons Dis | 2026 | 0 |
| Aberrant Protein S-Nitrosylation Mimics the Effect of Rare Genetic Mutations in [PMID:41635116] | Wang Y, Lipton SA | J Neurochem | 2026 | 0 |
| SNCA triplication disrupts proteostasis and extracellular architecture prior to [PMID:41698927] | Statoulla E, Zafeiri M, Chalkiadaki K, V | NPJ Parkinsons Dis | 2026 | 0 |
| Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's dise [PMID:41730496] | Panda SP, Saraswat N, Singh V | Neuroscience | 2026 | 0 |
| Degradation of alpha-synuclein/SNCA mRNA by RNautophagy. [PMID:41747943] | Kabuta C, Hakuno F, Kataoka N, Takahashi | Neurochem Int | 2026 | 0 |
| An update on the monogenic causes of Parkinson's disease: Impact on patient stra [PMID:41759745] | Asmi S, Krishnan A, Alexander SM, Mohame | Ageing Res Rev | 2026 | 0 |
| N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663] | Song P, Chen C, Franchini R, Duong B, Wa | J Clin Invest | 2026 | 0 |
| Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRI [PMID:41905621] | ["Singh R", "Maity P", "Jaiswal C"] | Neurochemistry international | 2026 | 0 |