Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AUTOPHAGY_PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AUTOPHAGY_PATHWAY |
| Key Genes/Proteins | STING, P62_SQSTM1, M2_PROTEIN, ATG5, MAVS |
| Related Diseases | APOPTOSIS, ACUTE_KIDNEY_INJURY, NEUROLOGICAL_DEFICITS |
| Related Pathways | AKT_MTOR, PI3K_AKT_MTOR, AUTOPHAGY_LYSOSOME, CGAS_STING |
Knowledge base pages for this entity
graph TD
AUTOPHAGY_PATHWAY["AUTOPHAGY_PATHWAY"]
AUTOPHAGY_PATHWAY -->|"inhibits"| STING["STING"]
AUTOPHAGY_PATHWAY -->|"regulates"| PEDV_N_protein["PEDV_N_protein"]
AUTOPHAGY_PATHWAY -->|"inhibits"| CGAS_STING["CGAS_STING"]
AUTOPHAGY_PATHWAY -->|"inhibits"| APOPTOSIS["APOPTOSIS"]
AUTOPHAGY_PATHWAY -->|"regulates"| p62["p62"]
AUTOPHAGY_PATHWAY -->|"regulates"| LC3["LC3"]
AUTOPHAGY_PATHWAY -->|"contributes to"| ACUTE_KIDNEY_INJURY["ACUTE_KIDNEY_INJURY"]
AUTOPHAGY_PATHWAY -->|"regulates"| MAVS["MAVS"]
AKT_MTOR["AKT_MTOR"] -->|"regulates"| AUTOPHAGY_PATHWAY
P62_SQSTM1["P62_SQSTM1"] -->|"regulates"| AUTOPHAGY_PATHWAY
PI3K_AKT_MTOR["PI3K_AKT_MTOR"] -->|"regulates"| AUTOPHAGY_PATHWAY
GNETUPENDIN_A["GNETUPENDIN_A"] -->|"activates"| AUTOPHAGY_PATHWAY
AUTOPHAGY_LYSOSOME["AUTOPHAGY_LYSOSOME"] -->|"activates"| AUTOPHAGY_PATHWAY
mTOR["mTOR"] -->|"inhibits"| AUTOPHAGY_PATHWAY
ATG5["ATG5"] -->|"participates in"| AUTOPHAGY_PATHWAY
METHAMPHETAMINE["METHAMPHETAMINE"] -->|"regulates"| AUTOPHAGY_PATHWAY| Target | Relation | Type | Str |
|---|---|---|---|
| STING | inhibits | protein | 0.72 |
| CGAS_STING | inhibits | pathway | 0.64 |
| APOPTOSIS | inhibits | phenotype | 0.64 |
| ACUTE_KIDNEY_INJURY | contributes_to | disease | 0.56 |
| MAVS | regulates | protein | 0.56 |
| NEUROLOGICAL_DEFICITS | activates | phenotype | 0.56 |
| BRAIN_INFARCT | inhibits | phenotype | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT_MTOR | regulates | pathway | 0.72 |
| P62_SQSTM1 | regulates | protein | 0.72 |
| PI3K_AKT_MTOR | regulates | pathway | 0.72 |
| GNETUPENDIN_A | activates | drug | 0.72 |
| AUTOPHAGY_LYSOSOME | activates | pathway | 0.72 |
| METHAMPHETAMINE | regulates | drug | 0.64 |
| M2_PROTEIN | inhibits | protein | 0.64 |
| THREE_MA | inhibits | drug | 0.64 |
| ATG5 | regulates | protein | 0.64 |
| LYSOSOMAL_DYSFUNCTION | inhibits | phenotype | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||