Are

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

Microglial TREM2 state determines whether C1q-tagged substrates are cleared adap

Score: 0.670 · neurodegeneration · 2026-04-25

This hypothesis reconciles conflicting C1q phenotypes by placing receiver-cell state downstream of a common upstream C1q

Vascular mural cell degeneration precedes and exacerbates parenchymal pathology

Score: 0.661 · alzheimers · 2026-04-04

## Mechanistic Overview Vascular mural cell degeneration precedes and exacerbates parenchymal pathology starts from the

Endosomal-Retromer Trafficking Defect as a Shared Sorting Failure

Score: 0.640 · neurodegeneration · 2026-04-28

Disrupted retrieval of cargo from endosomes to the trans-Golgi network (retromer dysfunction) impairs processing of APP,

early PD proteogenomic hubs that are both causal enough and accessible enough to

Score: 0.626 · neurodegeneration · 2026-04-28

early PD proteogenomic hubs that are both causal enough and accessible enough to perturb should produce a measurable pro

LYTL and JIP4-dependent lysosomal remodeling may show mutant-selective amplifica

Score: 0.580 · neurodegeneration · 2026-04-24

A more mechanistic but less translationally mature possibility is that G2019S does not strongly alter total phospho-Rab

Circadian-Gated Maresin Biosynthesis Amplification

Score: 0.557 · neurodegeneration · 2026-04-02

## Mechanistic Overview Circadian-Gated Maresin Biosynthesis Amplification starts from the claim that modulating ALOX12

Disease-Elevated CHI3L1/CHIT1 Chitinases Are Biomarkers and Partial Compensators

Score: 0.502 · als · 2026-04-26

CHI3L1 (YKL-40), CHIT1 (chitotriosidase), and CHI3L2 are among the most consistently elevated proteins in ALS biofluids

Rare TREM2-TYROBP pathway variants complement standard PRS by identifying microg

Score: 0.380 · late-onset-alzheimers · 2026-04-26

We hypothesize that rare loss-of-function variants in microglial-expressed genes within the TREM2-TYROBP signaling casca

Convergent NF-κB enhancers across diverse priming stimuli share therapeutic vuln

Score: 0.380 · alzheimers · 2026-04-26

Despite different initial triggers (LPS, β-amyloid, aging), primed microglia may converge on a common 'epigenetic primin

protective chromatin remodeling defines the therapeutic window for: Are DNA meth

Score: 0.345 · neurodegeneration · 2026-04-26

The same signal may be beneficial early and damaging late. Testing protective chromatin remodeling with single-cell meth

age-linked CpG drift is the actionable driver in: Are DNA methylation changes in

Score: 0.344 · neurodegeneration · 2026-04-26

The gap can be tested by treating age-linked CpG drift as an upstream driver rather than a passive correlate. If true, p

age-linked CpG drift is the actionable driver in: Are age-related DNA methylatio

Score: 0.344 · neurodegeneration · 2026-04-26

The gap can be tested by treating age-linked CpG drift as an upstream driver rather than a passive correlate. If true, p

ATAC-seq accessibility separates causal from compensatory states in: Are DNA met

Score: 0.342 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on ATAC-seq accessibility can distinguish harmful mechanisms from protective ada

Poorly lipidated APOE4 particles are preferentially routed through LDLR/LRP1 int

Score: 0.340 · molecular-biology · 2026-04-24

This is the weakest mechanistic proposal. It attempts to connect extracellular apoE particle quality to intracellular ER

ATAC-seq accessibility separates causal from compensatory states in: Are age-rel

Score: 0.327 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on ATAC-seq accessibility can distinguish harmful mechanisms from protective ada