Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Are: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammatory Mediators | regulates | process | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Senescent Microglia Resolution via Maresins-Senolytics Combi | 0.552 | neurodegeneration | Neuroinflammation resolution mechanisms |
| Vascular mural cell degeneration precedes and exacerbates pa | 0.520 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
| Near-infrared light therapy stimulates COX4-dependent mitoch | 0.514 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Circadian-Gated Maresin Biosynthesis Amplification | 0.471 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
epigenetics | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-15 | 0 hypotheses
neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the S [PMID:37738560] | Justice JN, Leng XI, LeBrasseur NK, Tchk | J Gerontol A Biol Sci Med Sci | 2024 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096] | Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li | Autophagy | 2023 | 1 |
| Sex differences in autophagy-mediated diseases: toward precision medicine. [PMID:32264724] | Shang D, Wang L, Klionsky DJ, Cheng H, Z | Autophagy | 2021 | 1 |
| Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populatio [PMID:33144684] | He D, Wang D, Lu P, Yang N, Xue Z, Zhu X | Oncogene | 2021 | 1 |
| BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. [PMID:32722981] | Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W | Autophagy | 2021 | 1 |
| ALOX12 is required for p53-mediated tumour suppression through a distinct ferrop [PMID:30962574] | Chu B, Kon N, Chen D, Li T, Liu T, Jiang | Nat Cell Biol | 2019 | 1 |
| Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. [PMID:30472260] | Singh NK, Rao GN | Prog Lipid Res | 2019 | 1 |
| An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-rep [PMID:29227475] | Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang | Nat Med | 2018 | 1 |
| Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells [PMID:26657143] | Chang J, Wang Y, Shao L, Laberge RM, Dem | Nat Med | 2016 | 1 |
| The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. [PMID:25754370] | Zhu Y, Tchkonia T, Pirtskhalava T, Gower | Aging Cell | 2015 | 1 |
| SIRT5 regulation of ammonia-induced autophagy and mitophagy. [PMID:25700560] | Polletta L, Vernucci E, Carnevale I, Arc | Autophagy | 2015 | 1 |
| Senolytic elimination of therapy-induced senescent cells by ABT-263 improves che [PMID:41423036] | Zhang D, Zhu J, Zou R, Zhang H, Yu BP, L | Biochemical pharmacology | 2026 | 0 |
| Comprehensive assessment of the genomic stability of human induced pluripotent s [PMID:41877289] | Zhang K, Na T, Jia C, Yuan X, Guo M, Yan | Stem cell research & therapy | 2026 | 0 |
| Characterization of the Direct and Indirect Inhibition of Apoptosis by Full-Leng [PMID:41589352] | Elsner C, Epasto LM, Cieren A, Gendreizi | Chembiochem : a European journ | 2026 | 0 |
| Exploring the key molecular mechanisms and immune microenvironment of oxidative [PMID:41591671] | Cai Z, Li J, Li T, Peng Q | Discover oncology | 2026 | 0 |
| Pharmacological and bioinformatics analysis reveals the reno-protective mechanis [PMID:41270547] | ["Ruiping L", "Yafeng W", "Liuyun L", "X | Computational biology and chem | 2026 | 0 |
| Hepatic Effects of Etoricoxib in Mice: Integrated Histopathological and Gene Exp [PMID:41901261] | ["Jamous Y", "Alghamdi B", "Jarrar Y", " | Pharmaceuticals (Basel, Switze | 2026 | 0 |
| Androgen Receptor-Induced Lactoferrin Accelerates Prostate Tumorigenesis Through [PMID:41945871] | Liu C, Peng Q, Zhang X, Li Z, Wu Y et al | Adv Sci (Weinh) | 2026 | 0 |