gene

NFE2L2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFE2L2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

885Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

View on Wiki →

🧬 Gene Info

Gene Symbol	NFE2L2
Full Name	Nuclear Factor Erythroid 2-Related Factor 2
Chromosome	2q31
Protein Family	bZIP transcription factor family, Cap'n'collar subfamily
Pathways	Autophagy, Chaperone, Epigenetic, Ferroptosis, Glutathione Synthesis
UniProt ID	Q16236
NCBI Gene ID	4780
Ensembl ID	ENSG00000116044
OMIM	604992
GeneCards	NFE2L2
Human Protein Atlas	NFE2L2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Cancer, Carcinoma, Hepatomegaly, Hepatoprotection
Known Drugs/Compounds	SFN, Ml385, Dimethyl Fumarate, Itaconate, Pterostilbene, dexamethasone
Interactions	HMOX1, FER, C1Q, HTRA2, MTOR, SIRT3
KG Connections	883 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFE2L2 — AlphaFold Q16236 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NFE2L2["NFE2L2"] -->|"Activates"| HMOX1["HMOX1"]
    NFE2L2["NFE2L2"] -->|"Regulates"| SOD["SOD"]
    NFE2L2["NFE2L2"] -->|"Regulates"| GPX["GPX"]
    NFE2L2["NFE2L2"] -->|"Regulates"| oxidative_stress["oxidative stress"]
    NFE2L2["NFE2L2"] -->|"Regulates"| antioxidant_response["antioxidant response"]
    NFE2L2["NFE2L2"] -->|"Regulates"| detoxifying_enzymes["detoxifying enzymes"]
    NFE2L2["NFE2L2"] -->|"Activates"| Cancer["Cancer"]
    NFE2L2["NFE2L2"] -->|"Activates"| Ms["Ms"]
    SQSTM1G427R["SQSTM1G427R"] -->|"Impairs"| NFE2L2["NFE2L2"]
    SQSTM1["SQSTM1"] -->|"Regulates"| NFE2L2["NFE2L2"]
    arsenic["arsenic"] -->|"Modulates"| NFE2L2["NFE2L2"]
    HACE1["HACE1"] -->|"Interacts With"| NFE2L2["NFE2L2"]
    SFN["SFN"] -->|"Activates"| NFE2L2["NFE2L2"]
    style NFE2L2 fill:#8d4900,color:#e0e0e0
    style HMOX1 fill:#8d4900,color:#e0e0e0
    style SOD fill:#0d47a1,color:#e0e0e0
    style GPX fill:#0d47a1,color:#e0e0e0
    style oxidative_stress fill:#1b5e20,color:#e0e0e0
    style antioxidant_response fill:#1b5e20,color:#e0e0e0
    style detoxifying_enzymes fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style SQSTM1G427R fill:#0d47a1,color:#e0e0e0
    style SQSTM1 fill:#0d47a1,color:#e0e0e0
    style arsenic fill:#00838f,color:#e0e0e0
    style HACE1 fill:#0d47a1,color:#e0e0e0
    style SFN fill:#00838f,color:#e0e0e0

Outgoing (515)

Target	Relation	Type	Str
Antioxidant Response	regulates	process	0.95
Microglial Activation	regulates	process	0.95
Hepatomegaly	causes	phenotype	0.94
Inflammation	inhibits	process	0.92
EGF	upregulates	gene	0.91
PDGF	upregulates	gene	0.91
SQSTM1	upregulates	gene	0.90
ANTIOXIDANT ENZYMES	upregulates	enzyme	0.90
PHASE-2 ENZYMES	upregulates	enzyme	0.90
Are	component_of	pathway	0.90
HO1	regulates	gene	0.90
HMOX1	upregulates	gene	0.90
HMOX1	regulates	gene	0.90
Spinal Cord Injury	targets	disease	0.90
Nerve Function Recovery	promotes	process	0.90
Antioxidant Function	mediates	process	0.90
GPX4	upregulates	gene	0.90
SLC7A11	upregulates	gene	0.90
Antioxidant Response	activates	pathway	0.90
Anti-Oxidative Stress Response	activates	pathway	0.90
Antioxidant Defense	mediates	process	0.90
Ferroptosis	protects_against	process	0.90
OXIDATIVE STRESS	upregulates	process	0.90
NEURODEGENERATION	protects_against	process	0.90
Autophagy	activates	pathway	0.90
ACOD1	regulates	gene	0.89
Lipotoxicity	protects_against	process	0.88
Spinal Cord Injury	protects_against	disease	0.88
Glutathione Synthesis	regulates	pathway	0.85
Stress Resistance	mediates	phenotype	0.85
Acute Ischemic Stroke	protects_against	disease	0.85
Neurological Dysfunction	protects_against	phenotype	0.85
Iron Metabolism	regulates	process	0.85
Remyelination	promotes	process	0.85
Mitochondrial Protection	mediates	process	0.85
HO1	upregulates	gene	0.85
NQO1	upregulates	gene	0.85
antioxidant capacity	upregulates	phenotype	0.85
Hepatic Lipid Homeostasis	mediates	process	0.85
Cancer	regulates	disease	0.85
Cancer	protects_against	disease	0.85
Ferroptosis	upregulates	process	0.85
Neuroprotection	mediates	process	0.85
Ferroptosis	inhibits	process	0.85
NFKB	modulates	protein	0.85
PI3K-AKT	upstream_of	pathway	0.85
senescence	regulates	process	0.85
Lipid Metabolism	regulates	process	0.85
Neuroinflammation	inhibits	process	0.85
Autophagy	mediates	process	0.85

Incoming (370)

Source	Relation	Type	Str
SQSTM1	activates	protein	1.00
KEAP1	interacts_with	protein	0.95
TGR5	activates	receptor	0.95
Itaconate	activates	compound	0.95
Leucocyanidin	activates	compound	0.95
SESN2	regulates	gene	0.95
Ric	upregulates	process	0.92
Ml385	inhibits	drug	0.92
SQSTM1G427R	inhibits	protein	0.90
SQSTM1	regulates	protein	0.90
CUL3	degrades	protein	0.90
RBX1	degrades	protein	0.90
Lead	promotes	drug	0.90
Dimethyl Fumarate	activates	drug	0.90
LRRK2	inhibits	gene	0.90
TFEB	regulates	protein	0.90
Pterostilbene	activates	compound	0.90
Quercetin	activates	compound	0.90
KEAP1	activates	gene	0.90
AUTOPHAGY	activates	gene	0.90
SQSTM1	upstream_of	protein	0.88
FYN	phosphorylates	protein	0.85
superoxide	activates	protein	0.85
Chronic Cerebral Hypoperfusion	downregulates	disease	0.85
White Matter Ischemia	associated_with	disease	0.85
SIRT3	activates	gene	0.85
SIRT3	upregulates	gene	0.85
AMPK-SIRT1 Pathway	activates	pathway	0.85
SBFI26	downregulates	drug	0.80
NRF2	activates	gene	0.80
P62	activates	gene	0.80
FERROPTOSIS	activates	gene	0.80
arsenic	regulates	drug	0.70
HACE1	interacts_with	protein	0.70
SFN	activates	drug	0.70
NRF2	associated_with	gene	0.70
NRF2	regulates	gene	0.70
GENES	activates	gene	0.70
AMPK	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
OXIDATIVE STRESS	causes	gene	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
VDR	activates	gene	0.64
KEAP1	inhibits	protein	0.64
ALOX5	activates	gene	0.60
HMOX1	activates	gene	0.60
ALOX15	activates	gene	0.60
ALOX12	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NFE2L2

Understanding Entity Pages

Summary

Wiki Pages (21)

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

NRF2 Oxidative Stress Pathway

dimethyl-fumarate-nrf2-ad-nct06850597

ALS Regional Onset and Spread: Network-Level Staging Model

Arsenic Exposure and Alzheimer's Disease Mechanism

RXRG — Retinoid X Receptor Gamma

Ferroptosis

CTSD Gene - Cathepsin D

tfeb-activators-neurodegeneration

SQSTM1 — Sequestosome 1 (p62)

Ferroptosis Pathway in Neurodegeneration

GSS Gene (Glutathione Synthetase)

Nrf2 Signaling in Neurodegeneration

NRF2 Activator Therapy for Neurodegeneration

PRKCA — Protein Kinase C Alpha

MAF - MAFA BZIP Transcription Factor

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

NRF2 Activators for Parkinson's Disease

SQSTM1/p62

NR1H3 - Nuclear Receptor Subfamily 1 Group H Member 3