gene

NFE2L2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFE2L2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

862Connections

3Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

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🧬 Gene Info

Gene Symbol	NFE2L2
Full Name	Nuclear Factor Erythroid 2-Related Factor 2
Chromosome	2q31
Protein Family	bZIP transcription factor family, Cap'n'collar subfamily
Pathways	Autophagy, Chaperone, Epigenetic, Ferroptosis, Glutathione Synthesis
UniProt ID	Q16236
NCBI Gene ID	4780
Ensembl ID	ENSG00000116044
OMIM	604992
GeneCards	NFE2L2
Human Protein Atlas	NFE2L2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Cancer, Carcinoma, Hepatomegaly, Hepatoprotection
Known Drugs/Compounds	dexamethasone, Dimethyl Fumarate, HBOT, Itaconate, Leucocyanidin, Ml385
Interactions	ACOX1, ACTB, Adiponectin, ADIPOQ, AGING, AKT
SciDEX Hypotheses	Nrf2 Pathway Activation Compensates for Progranuli NRF2 pathway activation to reduce mutant huntingti NRF2 Pathway Activation for Neuroprotection
KG Connections	859 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFE2L2 — AlphaFold Q16236 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

gene · 1644 words

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Pathway Diagram

graph TD
    NFE2L2["NFE2L2"] -->|"Activates"| HMOX1["HMOX1"]
    NFE2L2["NFE2L2"] -->|"Regulates"| SOD["SOD"]
    NFE2L2["NFE2L2"] -->|"Regulates"| GPX["GPX"]
    NFE2L2["NFE2L2"] -->|"Regulates"| oxidative_stress["oxidative stress"]
    NFE2L2["NFE2L2"] -->|"Regulates"| antioxidant_response["antioxidant response"]
    NFE2L2["NFE2L2"] -->|"Regulates"| detoxifying_enzymes["detoxifying enzymes"]
    NFE2L2["NFE2L2"] -->|"Activates"| Cancer["Cancer"]
    NFE2L2["NFE2L2"] -->|"Activates"| Ms["Ms"]
    SQSTM1G427R["SQSTM1G427R"] -->|"Impairs"| NFE2L2["NFE2L2"]
    SQSTM1["SQSTM1"] -->|"Regulates"| NFE2L2["NFE2L2"]
    arsenic["arsenic"] -->|"Modulates"| NFE2L2["NFE2L2"]
    HACE1["HACE1"] -->|"Interacts With"| NFE2L2["NFE2L2"]
    SFN["SFN"] -->|"Activates"| NFE2L2["NFE2L2"]
    style NFE2L2 fill:#8d4900,color:#e0e0e0
    style HMOX1 fill:#8d4900,color:#e0e0e0
    style SOD fill:#0d47a1,color:#e0e0e0
    style GPX fill:#0d47a1,color:#e0e0e0
    style oxidative_stress fill:#1b5e20,color:#e0e0e0
    style antioxidant_response fill:#1b5e20,color:#e0e0e0
    style detoxifying_enzymes fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style SQSTM1G427R fill:#0d47a1,color:#e0e0e0
    style SQSTM1 fill:#0d47a1,color:#e0e0e0
    style arsenic fill:#00838f,color:#e0e0e0
    style HACE1 fill:#0d47a1,color:#e0e0e0
    style SFN fill:#00838f,color:#e0e0e0

Outgoing (509)

Target	Relation	Type	Str
NFE2L2	encodes	protein	0.00
Microglial Activation	regulates	process	0.95
Antioxidant Response	regulates	process	0.95
Hepatomegaly	causes	phenotype	0.94
Inflammation	inhibits	process	0.92
PDGF	upregulates	gene	0.91
EGF	upregulates	gene	0.91
ANTIOXIDANT ENZYMES	upregulates	enzyme	0.90
GPX4	upregulates	gene	0.90
Ferroptosis	protects_against	process	0.90
Antioxidant Function	mediates	process	0.90
HO1	regulates	gene	0.90
Are	component_of	pathway	0.90
SQSTM1	upregulates	gene	0.90
HMOX1	regulates	gene	0.90
Nerve Function Recovery	promotes	process	0.90
Antioxidant Response	activates	pathway	0.90
ARE gene transcription	regulates	process	0.90
Anti-Oxidative Stress Response	activates	pathway	0.90
SLC7A11	upregulates	gene	0.90
Spinal Cord Injury	targets	disease	0.90
OXIDATIVE STRESS	upregulates	process	0.90
NRF2_pathway	regulates	pathway	0.90
NEURODEGENERATION	protects_against	process	0.90
Antioxidant Defense	mediates	process	0.90
HMOX1	upregulates	gene	0.90
PHASE-2 ENZYMES	upregulates	enzyme	0.90
Autophagy	activates	pathway	0.90
ACOD1	regulates	gene	0.89
Spinal Cord Injury	protects_against	disease	0.88
Lipotoxicity	protects_against	process	0.88
Ferroptosis	upregulates	process	0.85
Hepatic Lipid Homeostasis	mediates	process	0.85
antioxidant capacity	upregulates	phenotype	0.85
NFKB	modulates	protein	0.85
PI3K-AKT	upstream_of	pathway	0.85
HO1	upregulates	gene	0.85
Cancer	regulates	disease	0.85
NQO1	upregulates	gene	0.85
Cancer	protects_against	disease	0.85
Neuroprotection	mediates	process	0.85
Neuroinflammation	inhibits	process	0.85
Iron Metabolism	regulates	process	0.85
Remyelination	promotes	process	0.85
Neurological Dysfunction	protects_against	phenotype	0.85
senescence	regulates	process	0.85
Acute Ischemic Stroke	protects_against	disease	0.85
Mitochondrial Protection	mediates	process	0.85
Glutathione Synthesis	regulates	pathway	0.85
ferroptosis	inhibits	phenotype	0.85

Incoming (353)

Source	Relation	Type	Str
NFE2L2	encodes	gene	0.00
SQSTM1	activates	protein	1.00
SESN2	regulates	gene	0.95
Itaconate	activates	compound	0.95
Leucocyanidin	activates	compound	0.95
KEAP1	interacts_with	protein	0.95
TGR5	activates	receptor	0.95
Ric	upregulates	process	0.92
Ml385	inhibits	drug	0.92
Lead	promotes	drug	0.90
Pterostilbene	activates	compound	0.90
SQSTM1	regulates	protein	0.90
SQSTM1G427R	inhibits	protein	0.90
Quercetin	activates	compound	0.90
CUL3	degrades	protein	0.90
LRRK2	inhibits	gene	0.90
Dimethyl Fumarate	activates	drug	0.90
RBX1	degrades	protein	0.90
TFEB	regulates	protein	0.90
AUTOPHAGY	activates	gene	0.90
KEAP1	activates	gene	0.90
SQSTM1	associated_with	protein	0.88
KEAP1	component_of	gene	0.85
AMPK-SIRT1 Pathway	activates	pathway	0.85
superoxide	activates	protein	0.85
SIRT3	activates	gene	0.85
SIRT3	upregulates	gene	0.85
Chronic Cerebral Hypoperfusion	downregulates	disease	0.85
FYN	phosphorylates	protein	0.85
White Matter Ischemia	associated_with	disease	0.85
PRKCD	activates	gene	0.80
SBFI26	downregulates	drug	0.80
FERROPTOSIS	activates	gene	0.80
NRF2	activates	gene	0.80
P62	activates	gene	0.80
p300	regulates	protein	0.70
HACE1	interacts_with	protein	0.70
arsenic	regulates	drug	0.70
SFN	activates	drug	0.70
GENES	activates	gene	0.70
AMPK	activates	gene	0.70
OXIDATIVE STRESS	causes	gene	0.70
NRF2	associated_with	gene	0.70
NRF2	regulates	gene	0.70
HBOT	activates	drug	0.70
INFLAMMATION	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
KEAP1	inhibits	protein	0.64

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Nrf2 Pathway Activation Compensates for Progranulin Haploins	0.630	neurodegeneration	Test
NRF2 pathway activation to reduce mutant huntingtin aggregat	0.540	neurodegeneration	Test
NRF2 Pathway Activation for Neuroprotection	0.000	-	4R-tau strain-specific spreading pattern