gene

B4GALT7

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about B4GALT7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

B4GALT7 encodes a glycosyltransferase involved in proteoglycan synthesis, with mutations causing Ehlers-Danlos syndrome and potential roles in neurodegeneration

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🧬 Gene Info

Gene Symbol	B4GALT7
Full Name	Beta-1,4-Galactosyltransferase 7
Chromosome	9q33.1
Function	The B4GALT7 gene encodes beta-1,4-galactosyltransferase 7, a member of the beta-1,4-galactosyltransferase family
Primary Expression	Wide, high in brain
UniProt ID	[Q9NZH7](https://www.uniprot.org/uniprotkb/Q9NZH7/entry)
GeneCards	B4GALT7
Human Protein Atlas	B4GALT7
Acceptor	Xylosylated serine residues in core proteins
Donor	UDP-galactose
Kinetics	Higher activity toward oligosaccharide acceptors than monosaccharides
Syndecans	Cell surface proteoglycans that mediate cell-matrix interactions and signaling
Glypicans	GPI-anchored proteoglycans that regulate growth factor signaling
Perlecan	Basement membrane proteoglycan that supports neuronal survival
Aggrecan	Major component of the perineuronal net
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

B4GALT7 — Beta-1,4-Galactosyltransferase 7

gene · 1180 words

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Pathway Diagram

graph TD
    B4GALT7["B4GALT7"]
    style B4GALT7 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    neurodegeneration["neurodegeneration"]

    B4GALT7 -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class neurodegeneration disease

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning B4GALT7 in their description or question text

No additional research found