Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BACE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| APP | associated_with | protein | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso | 0.542 | neurodegeneration | What molecular mechanisms link elevated |
| BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb | 0.527 | neurodegeneration | What are the physiological functions of |
| Palmitoylation-Targeted BACE1 Trafficking Disruptors | 0.407 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Blocking palmitoyl-transferase activity reduces BACE1 membrane localization and [PMID:23395894] | Unknown | Molecular Neurodegeneration | 0 | |
| Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast [PMID:41558820] | Nishioka K, Ikezaki M, Iwahashi N, Araka | Life Sci Alliance | 2026 | 0 |
| An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzh [PMID:41696149] | Fang W, Zhao J, Li L, Wang Y, Xu ZP et a | Mater Today Bio | 2026 | 0 |
| Anti-ASC antibodies alleviate Alzheimer's disease-type pathology in APP/PS1 mice [PMID:41707905] | He L, Xiaopeng Z, Juan D, Yan L | Neuroscience | 2026 | 0 |
| Intranasal administration of neural stem cell-derived extracellular vesicles pre [PMID:41923110] | Natale F, Dellaria A, Nifo Sarrapochiell | Alzheimer's research & therapy | 2026 | 0 |
| Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's diseas [PMID:41930874] | Xiao S, Han Y, Yan J, Wu L, Lin H et al. | Int Immunopharmacol | 2026 | 0 |
| Repurposing FDA-approved drugs as multi-target neuroprotective agents for Alzhei [PMID:41946775] | Phemphunananchai K, Waiwut P, Phetcharab | Scientific reports | 2026 | 0 |
| Nano-magnolol enhances the modulatory effects of magnolol on cognitive performan [PMID:41954680] | Youssef B, Ibrahim EA, Moselhy SS, ElShe | Discov Nano | 2026 | 0 |
| BACE-1 inhibitors as potential drug candidates for treatment of Alzheimer's dise [PMID:41966670] | Kaur N, Gupta S, Bansal G, Bansal Y | Mol Divers | 2026 | 0 |
| Alzheimer's disease basics: we all should know. [PMID:40639927] | Das S | Neurological research | 2026 | 0 |
| Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in [PMID:41482106] | Kaur A, Singh S, Singh M, Silakari P, Ma | Experimental neurology | 2026 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J, Yi | CNS neuroscience & therapeutic | 2025 | 0 |
| Proposed Therapeutic Strategy to Combat Alzheimer's Disease by Targeting Beta an [PMID:40491367] | ["Kumar D", "Anand P", "Singh S"] | Current Alzheimer research | 2025 | 0 |
| BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitabili [PMID:40015276] | Bi D, Bao H, Yang X, Wu Z, Yang X, Xu G, | Neuron | 2025 | 0 |
| Unmasking BACE1 in aging and age-related diseases. [PMID:36509631] | ["Bao H", "Shen Y"] | Trends in molecular medicine | 2023 | 0 |
| BACE1: More than just a β-secretase. [PMID:35119166] | ["Taylor H", "Przemylska L", "Clavane E" | Obesity reviews : an official | 2022 | 0 |
| The β-Secretase BACE1 in Alzheimer's Disease. [PMID:32223911] | ["Hampel H", "Vassar R", "De Strooper B" | Biological psychiatry | 2021 | 0 |
| Early elevation of BACE1 in dementia. [PMID:34845111] | Cervellati C, Valacchi G, Zuliani G | Aging | 2021 | 0 |
| Identification of tell-tale patterns in the 3' non-coding region of hantaviruses [PMID:29559625] | Sankar S, Borkakoti J, Ramamurthy M, Nan | Emerging microbes & infections | 2018 | 0 |