| Gene Symbol | APP |
| Full Name | BACE1-Fe65 Complex |
| Chromosome | 21q21.3 |
| Protein Type | Protein |
| Function | is a type I transmembrane glycoprotein that plays a central role in the pathogenesis of Alzheimer's disease (AD). |
| Primary Expression | Ubiquitous, highest in brain |
| Subcellular Localization | of APP processing is critical—BACE1 activity is highest in lipid rafts, specialized membrane microdomains rich in choles |
| Molecular Weight | ~110 kDa |
| Exons | 18 |
| Pathways | Amyloid, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier |
| UniProt ID | P05067 |
| NCBI Gene ID | 351 |
| Ensembl ID | ENSG00000142192 |
| OMIM | 104760 |
| GeneCards | APP |
| Human Protein Atlas | APP |
| Associated Diseases | AD, ALS, AMI, AMYLOIDOSIS, ASTROGLIOSIS, ATHEROSCLEROSIS |
| Known Drugs/Compounds | LIRAGLUTIDE, DASATINIB, RAPAMYCIN, DIMETHYL FUMARATE, NICOTINAMIDE, MEMANTINE |
| Interactions | EIF2AK2, S100B, C1Q, TGM2, GPNMB, HMGB1 |
| SciDEX Hypotheses | Selective Cholinergic Protection via APP Pathway M |
| KG Connections | 4431 knowledge graph edges |
| Databases | GeneCardsHPASTRING |