gene

BAG5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

BAG5 (BCL2-associated athanogene 5) multi-domain co-chaperone, involved in Parkinson's disease, mitochondrial quality control, and alpha-synuclein aggregation

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🧬 Gene Info

Gene Symbol	BAG5
Full Name	BCL2-Associated Athanogene 5
Chromosome	14q32.33
Protein Family	BAG family, Hsp70 co-chaperones
Protein Type	Chaperone
Function	is a multi-domain co-chaperone protein that plays critical roles in neuronal survival, protein quality control, mitochondrial dynamics, and autophagy regulation.
Primary Expression	vulnerable neuronal populations including dopaminergic neurons of the substantia nigra pars compacta, cortical neurons, hippocampal neurons, and cereb
Subcellular Localization	, including nuclear localization signals and mitochondrial targeting sequences. This enables BAG5 to function in multipl
Molecular Weight	49 kDa
Amino Acids	446 aa
Exons	17
UniProt ID	[Q9NS69](https://www.uniprot.org/uniprot/Q9NS69)
Ensembl ID	ENSG00000164478
GeneCards	BAG5
Human Protein Atlas	BAG5
Associated Diseases	Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BAG5 Gene

gene · 3224 words

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BAG5 Protein

protein · 1102 words

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Pathway Diagram

graph TD
    BAG5["BAG5"]
    style BAG5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    neurodegeneration["neurodegeneration"]

    BAG5 -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class neurodegeneration disease

Outgoing (0)

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No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAG5 in their description or question text

No additional research found