Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BCLXL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BCL2L1 (BCL-XL) - anti-apoptotic BCL2 family protein with critical roles in neuronal survival, mitochondrial integrity, and neurodegeneration
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| Gene Symbol | BCLXL |
| Full Name | BCL2 Like 1 |
| Aliases | BCL-XL |
| Chromosome | 20q11.21 |
| Molecular Weight | 26 kDa |
| Amino Acids | 233 aa |
| Exons | 3 |
| UniProt ID | Q07817 |
| NCBI Gene ID | 598 |
| Ensembl ID | ENSG00000171552 |
| OMIM | 603354 |
| GeneCards | BCLXL |
| Human Protein Atlas | BCLXL |
| Transcription factors | NF-κB, p53, STAT3 |
| Hormonal regulation | Estrogen can upregulate BCLXL |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
BCLXL["BCLXL"]
neurodegeneration["neurodegeneration"]
BCLXL -->|"implicated_in"| neurodegeneration
style BCLXL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BCLXL in their description or question text
No additional research found