gene

CALCR

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CALCR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CALCR encodes the calcitonin receptor, a GPCR involved in calcium homeostasis with emerging roles in neuroprotection, synaptic function, and neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	CALCR
Full Name	Calcitonin Receptor
Chromosome	7p21.1
Function	The CALCR gene encodes the Calcitonin Receptor (CTR), a class B (secretin family) G protein-coupled receptor (GPCR) that binds calcitonin, amylin, and related peptides
Primary Expression	dorsal horn neurons modulates pain transmission [@walk2023]
Pathways	MAPK, PI3K
UniProt ID	[P30988](https://www.uniprot.org/uniprot/P30988)
Ensembl ID	ENSG00000104960
OMIM	114160
GeneCards	CALCR
Human Protein Atlas	CALCR
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CALCR — Calcitonin Receptor

gene · 1317 words

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Pathway Diagram

graph TD
    CALCR["CALCR"]
    neurodegeneration["neurodegeneration"]
    CALCR -->|"implicated_in"| neurodegeneration
    style CALCR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CALCR in their description or question text

No additional research found