gene

CALM4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALM4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CALM4 encodes a brain-specific calmodulin isoform that regulates calcium-dependent signaling in neurons, with roles in synaptic plasticity, ion channel modulation, and neurodegenerative disease pathways.

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🧬 Gene Info

Gene Symbol	CALM4
Full Name	Calmodulin 4
Chromosome	2p21
Function	encodes a brain-specific calmodulin isoform that plays critical roles in calcium-dependent signaling within neurons.
Molecular Weight	16.8 kDa
Amino Acids	149 aa
UniProt ID	Q9NP98
NCBI Gene ID	81631
Ensembl ID	ENSG00000170088
OMIM	614504
GeneCards	CALM4
Human Protein Atlas	CALM4
N-terminal domain	Contains two EF-hand calcium-binding motifs
Central linker	Flexible hinge region connecting N- and C-terminal domains
C-terminal domain	Contains two additional EF-hand motifs
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CALM4 — AlphaFold Q9NP98 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CALM4 — Calmodulin 4

gene · 3697 words

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Pathway Diagram

graph TD
    CALM4["CALM4"]
    neurodegeneration["neurodegeneration"]
    CALM4 -->|"implicated_in"| neurodegeneration
    style CALM4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALM4 in their description or question text

No additional research found