gene

CARS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CARS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

Summary

Cysteinyl-tRNA Synthetase 1 - essential enzyme in protein synthesis with extra-translational functions

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🧬 Gene Info

Gene Symbol	CARS1
Aliases	Cysteinyl-tRNA Synthetase 1
Chromosome	11p15.5
Protein Type	Enzyme
Function	encodes an essential enzyme responsible for the attachment of the amino acid cysteine to its cognate tRNA molecules.
Subcellular Localization	CARS1 localizes to multiple compartments:
Amino Acids	750 aa
UniProt ID	P49589
NCBI Gene ID	8438
Ensembl ID	ENSG00000198055
GeneCards	CARS1
Human Protein Atlas	CARS1
Associated Diseases	ALS
Interactions	TLR2
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CARS1 — AlphaFold P49589 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CARS1

gene · 1528 words

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Pathway Diagram

flowchart TD
    N0["CARS1"]
    N1["ALS"]
    N0 -->|"associated with"| N1
    N2["TLR2"]
    N0 -->|"co expressed with"| N2
    N3["neurodegeneration"]
    N0 -->|"implicated in"| N3

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene

Outgoing (6)

Target	Relation	Type	Str
ALS	associated_with	disease	0.60
RNA	associated_with	gene	0.60
TLR	associated_with	gene	0.60
TLR2	associated_with	gene	0.60
TLR2	activates	gene	0.60
TLR2	co_expressed_with	gene	0.50

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CARS1 in their description or question text

No additional research found