concept

TLR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

751Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TLR is a concept in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 477 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TLR
Summary	Comprehensive analysis of Toll-like receptor signaling in Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases, including mechanisms, therapeutic targets, and clinical trials
Key Genes/Proteins	INFLAMMATION, ACOD1
Related Diseases	Als, Inflammation, Cancer
Related Pathways	Toll-Like Receptor, innate immunity, Immune Response, JAK-STAT signaling
Linked Hypotheses	2 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TLR["TLR"]
    TLR -->|"activates"| innate_immunity["innate immunity"]
    TLR -->|"activates"| ACOD1["ACOD1"]
    TLR -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    TLR -->|"target for"| Cardiovascular["Cardiovascular"]
    TLR -->|"target for"| Inflammation["Inflammation"]
    TLR -->|"target for"| Als["Als"]
    TLR -->|"target for"| Cancer["Cancer"]
    TLR -->|"target for"| Ms["Ms"]
    TLR -->|"target for"| Tumor["Tumor"]
    TLR -->|"target for"| Autoimmune["Autoimmune"]
    MTOR["MTOR"] -->|"regulates"| TLR
    JAK["JAK"] -->|"interacts"| TLR
    PI3K["PI3K"] -->|"expressed in"| TLR
    BAX["BAX"] -->|"activates"| TLR
    NLRC5["NLRC5"] -->|"interacts"| TLR
    NLRP12["NLRP12"] -->|"interacts"| TLR
    CYTOKINES["CYTOKINES"] -->|"interacts"| TLR

Outgoing (518)

Target	Relation	Type	Str
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Toll-Like Receptor	activates	pathway	1.00
Inflammation	regulates	disease	0.95
innate immunity	activates	pathway	0.90
Toll-Like Receptor	associated_with	pathway	0.90
Immune Response	activates	pathway	0.90
Toll-Like Receptor	inhibits	pathway	0.90
Als	regulates	disease	0.85
Cancer	activates	disease	0.85
Cancer	regulates	disease	0.85
ACOD1	activates	gene	0.80
JAK-STAT signaling	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neuroinflammation	regulates	disease	0.80
Oxidative Stress	activates	pathway	0.80
Nf-Κb	activates	pathway	0.80
Nf-Κb	inhibits	pathway	0.80
Immune Response	regulates	pathway	0.80
Inflammation	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cardiovascular	regulates	disease	0.75
Tumor	activates	disease	0.75
Cardiac	activates	disease	0.75
Ischemia	therapeutic_target	disease	0.75
Inflammation	associated_with	disease	0.75
Obesity	activates	disease	0.75
Infection	activates	disease	0.75
Autoimmune	regulates	disease	0.75
Neurodegeneration	regulates	disease	0.75
melanoma	associated_with	disease	0.70
Proteasome	therapeutic_target	pathway	0.70
TNF-Α	activates	gene	0.70
Nf-Κb	regulates	pathway	0.70
Apoptosis	activates	pathway	0.70
Mtor	activates	pathway	0.70
UBIQUITIN	activates	gene	0.70
Innate Immunity	activates	pathway	0.70
Wnt	activates	pathway	0.70
Inflammasome	activates	pathway	0.70
STING	activates	gene	0.70
Inflammasome	regulates	pathway	0.70
ATG16L1	activates	gene	0.70
CANCER	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
INFLAMMATION	associated_with	gene	0.70
Autophagy	associated_with	pathway	0.70

Incoming (233)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
TLR4	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
NFKB	interacts_with	pathway	0.80
NF-ΚB	inhibits	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
NLRP3	regulates	gene	0.70
PI3K	inhibits	gene	0.70
APOPTOSIS	activates	gene	0.70
IL-6	activates	gene	0.70
NF-ΚB	regulates	gene	0.70
TNF	activates	gene	0.70
CYTOKINES	regulates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
TNF	inhibits	gene	0.70
JNK	activates	gene	0.70
NF-ΚB	activates	gene	0.70
CYTOKINES	activates	gene	0.70
rapamycin	targets	drug	0.70
ROS	regulates	gene	0.70
JAK	interacts_with	gene	0.60
PI3K	expressed_in	gene	0.60
JAK	regulates	gene	0.60
MTOR	activates	gene	0.60
JAK	activates	gene	0.60
BAX	activates	gene	0.60
NLRC5	interacts_with	gene	0.60
NLRP12	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
TRAF3	inhibits	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
IL6	regulates	gene	0.60
CCL4	activates	gene	0.60
CD4	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
TIRAP	activates	gene	0.60
TRAF6	activates	gene	0.60
ENO1	regulates	gene	0.60
TLR9	activates	gene	0.60
DNA	inhibits	gene	0.60
MTOR	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
PUMA	associated_with	gene	0.60
NOX	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam	0.617	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PK [PMID:40659086]	Li Z, Tan D, Lin J, Zhang T, Liu B et al	J Adv Res	2026	0
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease [PMID:40762111]	Cao F, Zhang P, Zheng Z, Wang P, Wang Y	Neurol Res	2026	0
CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis [PMID:41519399]	Zhang Y, Wang J, Song Y, Chai J, Li L et	Biochem Pharmacol	2026	0
Panax ginseng-derived Exosome-like Nanoparticles Prevent LPS-induced Septic Shoc [PMID:41530048]	Kim Y, Kim YK, Lee S, Kim M, Lee SW et a	Mol Pharm	2026	0
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026	0
2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota M [PMID:41926238]	Chen J, Liang S, Liu D, Yang S, Yan Q et	J Agric Food Chem	2026	0
Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peri [PMID:41926324]	Yan H, Chia D, Ernst S, Demuytere J, Cos	Expert Opin Drug Deliv	2026	0
Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877]	Miao J, Wang J, Zhou W, Guo J	Sci Rep	2026	0
Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promot [PMID:41930627]	Nakabo S, Hanata N, Patino-Martinez E, H	Arthritis Rheumatol	2026	0
In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV- [PMID:41931545]	Zheng N, Xu Y	PLoS Negl Trop Dis	2026	0
Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [PMID:41931597]	Ma B, Lyu W, Rizk J, Han X, Kjær M et al	Sci Immunol	2026	0
Reverse vaccinology and immunoinformatics Approaches Driven designing of a Novel [PMID:41934706]	Siddiquee NH, Al Mamun MA, Dremit TI, Ul	Hum Immunol	2026	0
MEX3B aggravates osteoarthritis progression by post-transcriptionally activating [PMID:41935341]	Fu Z, Huang Y, Zhang S, Chen J	J Orthop Surg Res	2026	0
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876]	Chen F, Xue Y, Ma X, Chen L, Shao Z et a	Adv Sci (Weinh)	2026	0
Molecular characterization and immunoinformatics-based design of a multi-epitope [PMID:41949632]	Asim M, Makki HH	Antonie Van Leeuwenhoek	2026	0
Zearalenone causes female reproductive lipotoxicity through the ERα-CD36/TLR4 si [PMID:41957128]	Dai C, Fu W, Huang Y, Li T, Ma Z et al.	Commun Biol	2026	0
Protective effect of nebivolol on bleomycin-induced lung fibrosis via suppressin [PMID:41960705]	Morsy MA, Abdel-Gaber SA, Abed El Baky M	Immunopharmacol Immunotoxicol	2026	0
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbat [PMID:41962542]	Zhang J, Huang Y, Chen Y, Zhang Y, Chen	Immunity	2026	0
Inhibition of TLR4/TRAF6/NF-κB pathway by empagliflozin mitigates concanavalin A [PMID:41964671]	El-Kashef DH, Shawky NO, Mahdi L, Sewila	Naunyn Schmiedebergs Arch Phar	2026	0

TLR

Understanding Entity Pages

Summary

Wiki Pages (21)

TLR Signaling Pathway in Neurodegeneration

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

CLCN10 — Chloride Voltage-Gated Channel 10

Mitochondrial Dysfunction in Neurodegeneration

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

PMN310 Anti-Amyloid for AD (NCT06750432)

Amyloid Cascade Pathway

Glia-Neuron Crosstalk in Alzheimer's Disease

Amyloid-Beta Aggregation and Plaque Formation

NF-kB Signaling Pathway in Neurodegeneration

DDX3X Gene

NF-κB Signaling Pathway in Neurodegeneration

Necroptotic Neurons

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Advanced Glycation End Products in Neurodegeneration

Amyloid Precursor Protein (APP)

Neuroinflammation in Parkinson's Disease