CASP14

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Caspase 14 - an executioner caspase primarily involved in keratinocyte differentiation and epidermal barrier formation

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flowchart TD
    N0["CASP14"]
    N1["Epidermis"]
    N0 -->|"expressed in"| N1
    N2["Keratinocyte Terminal Differentiation"]
    N0 -->|"involved in"| N2
    N3["KLK7"]
    N3 -->|"activates"| N0
    N4["PROCASPASE-14"]
    N4 -->|"product of"| N0
    N5["Corneocyte Formation"]
    N0 -->|"involved in"| N5
    N6["CASPASE14"]
    N0 -->|"encodes"| N6
    N7["Hair Follicles"]
    N0 -->|"expressed in"| N7
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8
    N9["Apoptosis"]
    N0 -->|"involved in"| N9
    N10["Inflammation"]
    N0 -->|"involved in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N4 protein
    class N6 protein