Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD3G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CD3G encodes the CD3 gamma subunit, a critical component of the T-cell receptor complex involved in immune regulation and neurodegenerative disease pathogenesis.
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| Gene Symbol | CD3G |
| Full Name | CD3 Gamma Subunit |
| Chromosome | 11q23.3 |
| Protein Type | Receptor |
| Function | Without CD3γ, TCR complexes fail to reach the cell surface, leading to severe T-cell immunodeficiency[@clements1994]. |
| Primary Expression | T lymphocytes, where it plays a fundamental role in translating antigen recognition into intracellular signaling events that drive T-cell responses |
| UniProt ID | P09693 |
| NCBI Gene ID | 915 |
| Ensembl ID | ENSG00000160654 |
| OMIM | 186740 |
| GeneCards | CD3G |
| Human Protein Atlas | CD3G |
| Promoter region | Contains elements for T-cell-specific expression |
| Exon regions | Encode the extracellular, transmembrane, and cytoplasmic domains |
| Regulatory elements | Include enhancers and silencers for proper expression in T-cells |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CD3G["CD3G"]
neurodegeneration["neurodegeneration"]
CD3G -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CD3G in their description or question text
No additional research found