Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHCHD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHCHD3 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3) is a mitochondrial protein involved in cristae organization and neuronal survival
| Gene Symbol | CHCHD3 |
| Full Name | Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 |
| Function | CHCHD3 encodes a mitochondrial protein containing twin coiled-coil helix (CHCH) domains. |
| Subcellular Localization | the **mitochondrial intermembrane space** where it forms homooligomers and heterooligomers with other CHCHD proteins |
| Amino Acids | 450 aa |
| UniProt ID | CHCHD3 |
| Ensembl ID | ENSG00000165237 |
| GeneCards | CHCHD3 |
| Human Protein Atlas | CHCHD3 |
| Mitochondrial cristae structure | Essential for maintaining mitochondrial cristae morphology |
| Respiratory chain function | Supports complex I and IV activity |
| Mitochondrial DNA maintenance | Protects mitochondrial genome integrity |
| Cell survival | Prevents apoptosis through mitochondrial pathways |
| Associated Diseases | neurodegeneration |
| Interactions | RB1CC1 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHCHD3["CHCHD3"]
mitochondrial_ROS["mitochondrial ROS"]
RB1CC1["RB1CC1"]
neurodegeneration["neurodegeneration"]
CHCHD3 -->|"contributes to"| mitochondrial_ROS
RB1CC1 -->|"activates"| CHCHD3
CHCHD3 -->|"implicated in"| neurodegeneration
style CHCHD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style mitochondrial_ROS fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
style RB1CC1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| mitochondrial ROS | contributes_to | phenotype | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RB1CC1 | activates | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||