gene

RB1CC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RB1CC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1194Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

RB1CC1 (FIP200) - autophagy initiation scaffold protein, key in neurodegeneration

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🧬 Gene Info

Gene Symbol	RB1CC1
Aliases	FIP200
Chromosome	8q11.23
Protein Type	Kinase
Function	encodes a large scaffolding protein that plays essential roles in autophagy, mitophagy, cell cycle regulation, and tumor suppression.
Molecular Weight	200 kDa
Amino Acids	894 aa
Pathways	Akt, Apoptosis, Autophagy, Car-T, Immunotherapy
UniProt ID	Q8TDW5
NCBI Gene ID	9821
Ensembl ID	ENSG00000051596
OMIM	606082
GeneCards	RB1CC1
Human Protein Atlas	RB1CC1
Associated Diseases	AD, ALI, ALS, Alzheimer, Cancer
Known Drugs/Compounds	rapamycin
Interactions	MFN1, ERN1, PARKIN, FMR1, SNCA, FAM134B
KG Connections	1194 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RB1CC1 — AlphaFold Q8TDW5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RB1CC1["RB1CC1"] -->|"interacts"| Dementia["Dementia"]
    RB1CC1["RB1CC1"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    RB1CC1["RB1CC1"] -->|"interacts"| Als["Als"]
    RB1CC1["RB1CC1"] -->|"interacts"| Alzheimer["Alzheimer"]
    RB1CC1["RB1CC1"] -->|"interacts"| Parkinson["Parkinson"]
    RB1CC1["RB1CC1"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| RB1CC1["RB1CC1"]
    OPTN["OPTN"] -->|"interacts"| RB1CC1["RB1CC1"]
    DNM1L["DNM1L"] -->|"interacts"| RB1CC1["RB1CC1"]
    CANX["CANX"] -->|"interacts"| RB1CC1["RB1CC1"]
    style RB1CC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (567)

Target	Relation	Type	Str
CD19 CAR-T cell cytotoxicity	protects_against	phenotype	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagy Initiation	involved_in	process	0.87
neurite growth	activates	phenotype	0.80
RB1	regulates	gene	0.80
ELP3	interacts_with	protein	0.80
CHCHD3	activates	gene	0.80
SQSTM1	regulates	gene	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
Autophagy	associated_with	pathway	0.80
Tumor	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
Als	associated_with	disease	0.75
WIPI2	associated_with	gene	0.70
NBR1	associated_with	gene	0.70
MTOR	associated_with	gene	0.70
autophagy	regulates	process	0.70
FIP200	encodes	protein	0.70
STING1	regulates	gene	0.70
TFEB	regulates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
SNAP29	regulates	gene	0.70
STX17	regulates	gene	0.70
ULK1	regulates	gene	0.70
Mtor	associated_with	pathway	0.70
Apoptosis	associated_with	pathway	0.70
Toll-Like Receptor	associated_with	pathway	0.70
Autophagy	inhibits	pathway	0.70
ROS	activates	gene	0.70
Parkinson's disease	activates	disease	0.70
oxidative stress response	participates_in	pathway	0.70
necroptosis	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
RUBCNL	activates	gene	0.70
ROS	regulates	gene	0.70
Parkinson's disease	regulates	disease	0.70
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	inhibits	disease	0.65
Cancer	regulates	disease	0.65

Incoming (627)

Source	Relation	Type	Str
lipid ROS	activates	phenotype	0.90
STBD1	interacts_with	protein	0.90
STBD1	binds	protein	0.90
FIP200	regulates	gene	0.80
LC3	regulates	gene	0.80
NBR1	regulates	gene	0.80
OPTN	regulates	gene	0.80
MTOR	regulates	gene	0.80
rapamycin	targets	drug	0.80
ATG	regulates	gene	0.80
LC3	associated_with	gene	0.80
RB1	associated_with	gene	0.80
OPTN	associated_with	gene	0.70
CALCOCO2	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
GABARAP	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
PIK3C3	associated_with	gene	0.70
TFEB	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
CALCOCO2	regulates	gene	0.70
DDIT3	regulates	gene	0.70
DNM1L	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
ERN1	regulates	gene	0.70
JNK	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
NDP52	regulates	gene	0.70
PRKN	regulates	gene	0.70
GABARAP	regulates	gene	0.70
PIK3C3	regulates	gene	0.70
ATG	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
DNA	activates	gene	0.70
NLR	activates	gene	0.70
AMPK	regulates	gene	0.70
DNA	regulates	gene	0.70
NLR	regulates	gene	0.70
GABA	regulates	gene	0.70
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RB1CC1

Understanding Entity Pages

Summary

Wiki Pages (21)

RB1CC1 Gene

fip200

CBS Autophagy-Lysosomal Pathway Dysfunction

ATG17A

SNCAIP Gene

STK4 — Serine/Threonine Kinase 4

CFTR Gene

ATG17 Gene

ATG13 — Autophagy Related 13

TAX1BP1 Gene

ULK1 — UNC-51 Like Kinase 1

PEX3 Gene - Peroxisome Biogenesis Factor 3

atg16l1

KAT8 Gene

EIF2α Protein

ATM Gene

RB1 — Retinoblastoma 1

RB1 Protein (Retinoblastoma Protein)

ATG1