Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRM5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHRM5 encodes the M5 muscarinic acetylcholine receptor, a GPCR expressed in brain regions implicated in Alzheimer's and Parkinson's disease, with roles in cognition, dopamine regulation, and neuroprotection.
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| Gene Symbol | CHRM5 |
| Full Name | Cholinergic Receptor Muscarinic 5 |
| Chromosome | 15q26 |
| Protein Family | GPCR, Class A, Muscarinic receptors |
| Protein Type | Receptor |
| Function | is a member of the muscarinic acetylcholine receptor family, which consists of five subtypes (M1-M5) that belong to the G protein-coupled receptor (GPCR) superfamily. |
| Amino Acids | 532 aa |
| Pathways | cascade: ```mermaid |
| UniProt ID | P08912 |
| NCBI Gene ID | 1129 |
| Ensembl ID | ENSG00000121966 |
| OMIM | 118491 |
| GeneCards | CHRM5 |
| Human Protein Atlas | CHRM5 |
| Non-selective muscarinic agonists | Oxotremorine, pilocarpine, carbachol (activate all subtypes) |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHRM5["CHRM5"]
neurodegeneration["neurodegeneration"]
CHRM5 -->|"implicated_in"| neurodegeneration
style CHRM5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CHRM5 in their description or question text
No additional research found