Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CING1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CING1 |
| Full Name | Cingulin |
| Chromosome | 7p21.1 |
| Protein Family | Cingulin family |
| Function | is a cytoskeletal protein originally identified at the cytoplasmic surface of tight junctions in epithelial and endothelial cells. |
| Primary Expression | neuronal tissues, where it localizes to the postsynaptic density and plays important roles in synaptic organization, neuronal polarity, and potentiall |
| Molecular Weight | 140 kDa |
| UniProt ID | Q9Z2X1 |
| NCBI Gene ID | 10484 |
| Ensembl ID | ENSG00000152240 |
| OMIM | 604267 |
| GeneCards | CING1 |
| Human Protein Atlas | CING1 |
| Scaffold function | Connects transmembrane tight junction proteins (claudins, occludin) to the actin cytoskeleton |
| Barrier regulation | Modulates paracellular permeability to ions and molecules |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CING1["CING1"]
neurodegeneration["neurodegeneration"]
CING1 -->|"implicated_in"| neurodegeneration
style CING1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CING1 in their description or question text
No additional research found