gene

COA6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Mitochondrial complex IV assembly factor involved in cytochrome c oxidase biogenesis and linked to Leigh syndrome and neurodegeneration.

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🧬 Gene Info

Gene Symbol	COA6
Full Name	Cytochrome c Oxidase Assembly Factor 6
Chromosome	1q23.3
Function	is a small mitochondrial protein that plays a critical role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain.
Subcellular Localization	the mitochondrial inner membrane. Pathogenic variants in COA6 cause severe mitochondrial disorders, including Leigh synd
Molecular Weight	12 kDa
Amino Acids	87 aa
Exons	3
GeneCards	COA6
Human Protein Atlas	COA6
Mitochondrial targeting peptide	First 20 amino acids form an amphipathic helix
Copper-binding motif	Conserved CxC sequence for copper coordination
Hydrophobic core	Transmembrane domain anchoring to inner membrane
Interaction surfaces	Regions for SCO1, SCO2, and COX1 binding
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

COA6 Gene - Cytochrome c Oxidase Assembly Factor 6

gene · 3019 words

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COA6 Protein (Cytochrome C Oxidase Assembly Factor 6)

protein · 769 words

→

Pathway Diagram

graph TD
    COA6["COA6"]
    neurodegeneration["neurodegeneration"]
    COA6 -->|"implicated_in"| neurodegeneration
    style COA6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning COA6 in their description or question text

No additional research found