Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COMPLEX I: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| ROS production | associated_with | phenotype | 0.90 |
| Mitochondrial Dysfunction | involved_in | process | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CRISPR-Mediated Mitochondrial Genome Editing for Complex I D | 0.681 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Mitochondrial ROS from complex I and cardiolipin instability | 0.640 | neurodegeneration | What mechanisms drive the self-amplifyin |
| VPS34 Complex I Subunit Heterogeneity Dictates Organelle-Spe | 0.571 | neurodegeneration | How do different organelle-specific auto |
| Nuclear Pore Complex Integrity as Proteostasis Checkpoint Fa | 0.460 | neurodegeneration | Test |
| Ginsenoside Rb1 Analogs for Complex I-Mediated Neuroprotecti | 0.000 | - | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.833
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning COMPLEX I in their description or question text
No additional research found