concept

METFORMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METFORMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

581Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	METFORMIN
Related Diseases	Type 2 Diabetes, Insulin Resistance, Mitochondrial Membrane Potential, Mitochondrial Density, NEURODEGENERATION
Related Pathways	Mitochondrial Biogenesis, Mitochondrial Dynamics, PI3K/AKT/mTOR, cGAS-STING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    METFORMIN["METFORMIN"]
    style METFORMIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    METFORMIN -->|"upregulates"| SIRT1([SIRT1])
    METFORMIN -->|"treats"| Hepatic_Steatosis["Hepatic Steatosis"]
    METFORMIN -->|"activates"| SIRT1_Mediated_Autophagy["SIRT1-Mediated Autophagy"]
    METFORMIN -->|"treats"| Cognitive_Impairment(Cognitive Impairment)
    METFORMIN -->|"activates"| AMPK([AMPK])
    METFORMIN -.->|"inhibits"| astrocyte_senescence["astrocyte senescence"]
    METFORMIN -->|"modulates"| Mitochondrial_Biogenesis["Mitochondrial Biogenesis"]
    METFORMIN -->|"modulates"| Mitochondrial_Dynamics["Mitochondrial Dynamics"]
    METFORMIN -.->|"protects against"| Hippocampal_Neurodegeneration["Hippocampal Neurodegeneration"]

Outgoing (380)

Target	Relation	Type	Str
Type 2 Diabetes	treats	disease	0.90
Insulin Resistance	associated_with	phenotype	0.90
Atp Production	upregulates	process	0.85
Mitochondrial Membrane Potential	associated_with	phenotype	0.85
Complex I Activity	upregulates	process	0.85
Mitochondrial Density	associated_with	phenotype	0.85
Mitochondrial Biogenesis	modulates	biological_process	0.80
Mitochondrial Dynamics	modulates	biological_process	0.80
PI3K/AKT/mTOR	inhibits	pathway	0.80
cGAS-STING	attenuates	pathway	0.80
NEURODEGENERATION	treats	disease	0.80
PARKINSON'S DISEASE	treats	disease	0.80
ALZHEIMER'S DISEASE	treats	disease	0.80
HUNTINGTON'S DISEASE	treats	disease	0.80
MULTIPLE SCLEROSIS	treats	disease	0.80
antioxidant defenses	upregulates	biological_process	0.80
protein aggregation	inhibits	biological_process	0.80
AMPK	activates	protein	0.79
HEPATIC_STEATOSIS	treats	phenotype	0.72
ENDOTHELIAL_IMPAIRMENT	treats	phenotype	0.72
AUTOPHAGY	inhibits	pathway	0.72
HEDGEHOG_PATHWAY	activates	pathway	0.72
COGNITIVE_IMPAIRMENT	treats	phenotype	0.72
CANCER	inhibits	disease	0.70
STAT1	destabilizes	gene	0.70
FOXO1	activates	gene	0.70
TYPE 2 DIABETES	interacts_with	disease	0.70
T CELL	regulates	cell_type	0.65
STING	activates	gene	0.65
SIRT1	mediates	gene	0.65
PARKIN	contributes_to	gene	0.65
PARKINSON	contributes_to	disease	0.65
PARKINSON'S DISEASE	contributes_to	disease	0.65
NEURODEGENERATION	impairs	disease	0.65
TAU	impairs	gene	0.65
NEURON	protects_against	cell_type	0.65
NEURONS	protects_against	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
PI3K	phosphorylates	gene	0.65
T CELL	expressed_in	cell_type	0.65
NLRP3	activates	gene	0.65
TREM2	mediates	gene	0.65
STING	mediates	gene	0.65
MTOR	activates	gene	0.65
FIBROBLASTS	treats	cell_type	0.65
FIBROSIS	interacts_with	disease	0.65
MICROGLIA	inhibits	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
AUTOPHAGY	treats	phenotype	0.65
CELL DEATH	treats	phenotype	0.65

Incoming (201)

Source	Relation	Type	Str
AMPK	treats	gene	0.65
ENDOTHELIAL	causes	cell_type	0.65
DIABETES	contributes_to	disease	0.65
CA1	protects_against	brain_region	0.65
GFAP	protects_against	gene	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
DIABETES	treats	disease	0.65
BDNF	promotes	gene	0.65
CGAS	mediates	gene	0.65
SYK	regulates	gene	0.65
HEPATOCYTES	treats	cell_type	0.65
DIABETES	targets	disease	0.65
TREM2	protects_against	gene	0.65
TH	causes	gene	0.65
NICOTINAMIDE	activates	drug	0.65
NICOTINAMIDE	treats	drug	0.65
MLKL	inhibits	gene	0.65
MLKL	activates	gene	0.65
NEURONS	treats	cell_type	0.65
CYTOKINES	inhibits	phenotype	0.65
TNF	inhibits	gene	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
AMYLOID PLAQUES	protects_against	phenotype	0.65
PARKINSON'S DISEASE	targets	disease	0.65
AKT	regulates	gene	0.65
CCL2	inhibits	gene	0.65
AMPK	implicated_in	gene	0.55
AMPK	participates_in	gene	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
AUTOPHAGY	activates	process	0.50
AMPK	upregulates	gene	0.50
SIRT1	upregulates	gene	0.50
INFLAMMATION	associated_with	process	0.50
T CELL	inhibits	cell_type	0.50
AGING	protects_against	process	0.50
AGING	inhibits	process	0.50
TREM2	inhibits	gene	0.50
NEUROINFLAMMATION	inhibits	process	0.50
TREM2	regulates	gene	0.50
NEUROINFLAMMATION	regulates	process	0.50
NLRP3	activates	gene	0.50
MICROGLIA	activates	cell_type	0.50
TREM2	activates	gene	0.50
AMPK	activates	gene	0.50
SIRT1	activates	gene	0.50
SIRT1	associated_with	gene	0.50
AUTOPHAGY	associated_with	process	0.50
SIRT1	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

METFORMIN

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Parkinson's Disease

CBS/PSP Supplements Guide

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

CBS/PSP Treatment Rankings

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Vascular Cognitive Impairment (VCI)

Synaptic Vesicle Trafficking in Parkinson's Disease

nlrc5-protein

Mitochondrial Dysfunction in Neurodegeneration

Synucleinopathies

Gene-Mechanism-Therapy Causal Chains

Insulin Signaling in Parkinson's Disease

creatine-supplementation-neurodegeneration