gene

NDUFS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

1Hypotheses

1Analyses

43Outgoing

35Incoming

0Experiments

1Debates

Summary

NDUFS1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with Parkinson. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDUFS1
Function	The NDUFS1 gene encodes NDUFS1 Protein, a protein involved in various cellular processes relevant to neuronal function and survival.
Primary Expression	various brain regions, with notable expression in: - Cerebral cortex - Hippocampus - Basal gang
Pathways	Oxidative Phosphorylation, Oxidative Stress
Ensembl ID	ENSG00000156510
GeneCards	NDUFS1
Human Protein Atlas	NDUFS1
Associated Diseases	Parkinson
Interactions	ACO2, ATP, COX15, COX4I1, COX7A1, COX8A
SciDEX Hypotheses	Ginsenoside Rb1 Analogs for Complex I-Mediated Neu
KG Connections	78 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NDUFS1 Gene

gene · 588 words

→

NDUFS1 Protein

protein · 896 words

→

Pathway Diagram

graph TD
    NDUFS1["NDUFS1"]
    Parkinson{"Parkinson"}
    NDUFS1 -->|"therapeutic target"| Parkinson
    SDHA["SDHA"]
    NDUFS1 -->|"therapeutic target"| SDHA
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    NDUFS1 -->|"therapeutic target"| Oxidative_Phosphorylation
    Oxidative_Stress(["Oxidative Stress"])
    NDUFS1 -->|"therapeutic target"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    NDUFS1 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| NDUFS1
    VDAC1["VDAC1"]
    VDAC1 -->|"therapeutic target"| NDUFS1
    HSPA9["HSPA9"]
    HSPA9 -->|"therapeutic target"| NDUFS1
    CYCS["CYCS"]
    CYCS -->|"therapeutic target"| NDUFS1
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"therapeutic target"| NDUFS1
    ACO2["ACO2"]
    ACO2 -->|"therapeutic target"| NDUFS1
    GLUD1["GLUD1"]
    GLUD1 -->|"associated with"| NDUFS1
    SNCA["SNCA"]
    SNCA -->|"therapeutic target"| NDUFS1
    LRPPRC["LRPPRC"]
    LRPPRC -->|"associated with"| NDUFS1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"therapeutic target"| NDUFS1
    NDUFS2["NDUFS2"]
    NDUFS2 -->|"associated with"| NDUFS1
    style NDUFS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFS1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
COMPLEX I	regulates	protein	0.90
Parkinson	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
NDUFS2	causes	gene	0.60
GLUD1	causes	gene	0.60
VDAC1	therapeutic_target	gene	0.60
SNCA	therapeutic_target	gene	0.60
SNCA	activates	gene	0.60
SDHA	activates	gene	0.60
VDAC1	activates	gene	0.60
CYCS	activates	gene	0.60
NDUFS4	inhibits	gene	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
ATP	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
PARKINSON'S DISEASE	activates	gene	0.60
IMMUNE INFILTRATION	activates	gene	0.60
GENES	activates	gene	0.60
PARKINSON	activates	gene	0.60
Parkinson	associated_with	disease	0.60
CYCS	therapeutic_target	gene	0.60
HSPA9	therapeutic_target	gene	0.60
LRPPRC	causes	gene	0.60
ACO2	therapeutic_target	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
App	therapeutic_target	protein	0.60
SDHA	therapeutic_target	gene	0.60
oxidative stress response	participates_in	pathway	0.60
AND	causes	gene	0.60
T Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
NDUFS4	co_expressed_with	gene	0.50
NDUFS2	co_expressed_with	gene	0.50
NDUFS2	associated_with	gene	0.50
SDHA	co_expressed_with	gene	0.50

Incoming (35)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFS1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
Chronic Tendon Injury	downregulates	disease	0.85
GENES	therapeutic_target	gene	0.60
VDAC1	therapeutic_target	gene	0.60
HSPA9	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
ACO2	therapeutic_target	gene	0.60
GLUD1	associated_with	gene	0.60
SNCA	therapeutic_target	gene	0.60
LRPPRC	associated_with	gene	0.60
NDUFS2	associated_with	gene	0.60
GLUD1	causes	gene	0.60
LRPPRC	causes	gene	0.60
ACO2	activates	gene	0.60
HSPA9	activates	gene	0.60
ROS	activates	gene	0.60
ATP	activates	gene	0.60
COX15	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
COX7A1	inhibits	gene	0.60
COX8A	inhibits	gene	0.60
NDUFA12	inhibits	gene	0.60
NDUFA5	inhibits	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
HUB GENES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	therapeutic_target	gene	0.60
ATP	therapeutic_target	gene	0.60
HSPA9	co_expressed_with	gene	0.50
LRPPRC	co_expressed_with	gene	0.50
NDUFA12	co_expressed_with	gene	0.50
NDUFA5	co_expressed_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Ginsenoside Rb1 Analogs for Complex I-Mediated Neuroprotecti	0.000	-	Mitochondrial transfer between astrocyte

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.833

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning NDUFS1 in their description or question text

No additional research found