entity

CRP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

6Hypotheses

2Analyses

9Outgoing

1Incoming

0Experiments

2Debates

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Wiki Pages (1)

Knowledge base pages for this entity

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member 2

gene · 1180 words

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Outgoing (9)

Target	Relation	Type	Str
Recurrent Stroke	biomarker_for	disease	0.85
Macrophage Infiltration	contributes_to	process	0.85
Sepsis	biomarker_for	disease	0.85
cardiovascular risk	biomarker_for	disease	0.80
Liver Cirrhosis	risk_factor_for	disease	0.75
Septic Shock	biomarker_for	disease	0.70
C1q	associated_with	protein	0.70
NLRP3 inflammasome	activates	pathway	0.70
IL-1β	activates	protein	0.70

Incoming (1)

Source	Relation	Type	Str
30104698	not different in	paper	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective C1q-CRP vs. C1q-IgG Axis Inhibition	0.597	neuroinflammation	How does Alectinib, a kinase inhibitor,
Circulating hs-CRP as Disease-Modifying Target via Microglia	0.565	immunomics	Systemic immune profiling in neurodegene
Circulating hs-CRP as Disease-Modifying Target via Astrocyti	0.387	immunomics	Systemic immune profiling in neurodegene
CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL	0.380	immunomics	Systemic immune profiling in neurodegene
Circulating hs-CRP as Disease-Modifying Target via Astrocyti	0.380	immunomics	Systemic immune profiling in neurodegene

hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune	0.357	immunomics	Systemic immune profiling in neurodegene

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does Alectinib, a kinase inhibitor, achieve high-affinity binding to complem

neuroinflammation | 2026-04-16 | 5 hypotheses Top: 0.597

Systemic immune profiling in neurodegeneration: peripheral inflammation as drive

immunomics | 2026-04-16 | 13 hypotheses Top: 0.565

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Binding and complement activation by C-reactive protein via the collagen-like re [PMID:2005402]	["Jiang HX", "Siegel JN", "Gewurz H"]	J Immunol	1991	0

Debates (2)

Multi-agent debates referencing this entity

How does chronic peripheral inflammation interact with CNS neuroimmune pathways

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The abstract reports that Alectinib binds C1q with high affinity, but this is me

closed · Rounds: 4 · Score: 0.94 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CRP in their description or question text

hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune Privilege via IL-1β

Score: 0.357 · immunomics · 2026-04-26

Circulating hs-CRP directly triggers CCR2+ monocyte recruitment to the CNS by enhancing CCL2 expression in brain endothe