Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Sepsis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Associated Genes | AQP4, MMP9, S100A8, HIF, TREM2, CYTOKINES, AKT, MTOR |
| Therapeutic Agents | PCTR1 |
| KG Connections | 718 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Sepsis["<b>Sepsis</b>"]
Immune_Response["Immune Response"]
Sepsis -->|"activates"| Immune_Response
Acute_Kidney_Injury{"Acute Kidney Injury"}
Sepsis -->|"causes"| Acute_Kidney_Injury
Mortality["Mortality"]
Sepsis -->|"causes"| Mortality
Mtor["Mtor"]
Sepsis -->|"activates"| Mtor
Nf__b["Nf-Kappab"]
Sepsis -.->|"inhibits"| Nf__b
Ferroptosis["Ferroptosis"]
Sepsis -->|"activates"| Ferroptosis
AKT(["AKT"])
AKT -->|"activates"| Sepsis
Als{"Als"}
Als -->|"activates"| Sepsis
CYTOKINES(["CYTOKINES"])
CYTOKINES -->|"activates"| Sepsis
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"regulates"| Sepsis
style Sepsis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Immune Response | activates | pathway | 1.00 |
| Blood-Brain Barrier Disruption | causes | process | 0.95 |
| Immunosuppression | causes | process | 0.95 |
| Organ Dysfunction | causes | phenotype | 0.95 |
| Sepsis-Induced Immunosuppression | causes | process | 0.95 |
| Sepsis-Associated Encephalopathy | causes | disease | 0.95 |
| Acute Kidney Injury | causes | disease | 0.92 |
| Mortality | causes | phenotype | 0.90 |
| Acute Lung Injury | causes | disease | 0.90 |
| Septic Cardiomyopathy | causes | disease | 0.90 |
| Mtor | activates | pathway | 0.90 |
| Nf-Κb | inhibits | pathway | 0.90 |
| Ferroptosis | activates | pathway | 0.85 |
| Autophagy | associated_with | pathway | 0.85 |
| Apoptosis | activates | pathway | 0.85 |
| Inflammation | therapeutic_target | disease | 0.85 |
| Brain Inflammation | causes | process | 0.85 |
| Liver Injury | causes | phenotype | 0.85 |
| Antibiotic Overuse | contributes_to | phenotype | 0.80 |
| Early Diagnosis | associated_with | process | 0.80 |
| Nf-Κb | activates | pathway | 0.80 |
| Immune Response | causes | pathway | 0.80 |
| Autophagy | activates | pathway | 0.80 |
| Pyroptosis | activates | pathway | 0.80 |
| Oxidative Stress | inhibits | pathway | 0.80 |
| Mitophagy | activates | pathway | 0.75 |
| Inflammation | activates | disease | 0.75 |
| Glycolysis | activates | pathway | 0.70 |
| Epigenetic | activates | pathway | 0.70 |
| Mtor | regulates | pathway | 0.70 |
| Glycolysis | regulates | pathway | 0.70 |
| Adaptive Immunity | regulates | pathway | 0.70 |
| Innate Immunity | regulates | pathway | 0.70 |
| Toll-Like Receptor | therapeutic_target | pathway | 0.70 |
| Nf-Κb | therapeutic_target | pathway | 0.70 |
| Lipid Metabolism | therapeutic_target | pathway | 0.70 |
| Oxidative Stress | activates | pathway | 0.70 |
| Ferroptosis | associated_with | pathway | 0.70 |
| Apoptosis | treats | pathway | 0.70 |
| Inflammasome | treats | pathway | 0.70 |
| Apoptosis | inhibits | pathway | 0.70 |
| Oxidative Stress | regulates | pathway | 0.70 |
| Mapk | regulates | pathway | 0.70 |
| Mitophagy | inhibits | pathway | 0.70 |
| Apoptosis | therapeutic_target | pathway | 0.70 |
| Pi3K/Akt | activates | pathway | 0.70 |
| Obesity | activates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Autoimmune | regulates | disease | 0.65 |
| Histone Modification | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Infection | causes | disease | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| Cardiac | activates | disease | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| MTOR | activates | gene | 0.95 |
| Infection | activates | disease | 0.95 |
| Inflammation | activates | disease | 0.95 |
| Als | treats | disease | 0.95 |
| NF-ΚB | inhibits | gene | 0.95 |
| MITOCHONDRIA | activates | gene | 0.95 |
| Inflammation | associated_with | disease | 0.95 |
| Dysregulated Host Response | causes | mechanism | 0.95 |
| Glycocalyx | biomarker_for | biomarker | 0.92 |
| Dysregulated Host Response To Infection | causes | process | 0.90 |
| PCTR1 | protects_against | compound | 0.90 |
| Circular Rnas | biomarker_for | biomarker | 0.90 |
| Hoxa Distal Transcript Antisense Rna | biomarker_for | biomarker | 0.90 |
| PROC | biomarker_for | protein | 0.90 |
| Triiodothyronine | biomarker_for | compound | 0.90 |
| PKN2 | biomarker_for | protein | 0.90 |
| Early Inflammatory Onset | involved_in | process | 0.90 |
| Immunosuppression | involved_in | process | 0.90 |
| glycocalyx degradation | contributes_to | process | 0.90 |
| Dysregulated Thromboinflammation | causes | process | 0.90 |
| Glycocalyx | therapeutic_target | biomarker | 0.88 |
| BAX | activates | gene | 0.85 |
| Pericyte-Derived Extracellular Vesicles | treats | cell_type | 0.85 |
| NF-ΚB | activates | gene | 0.85 |
| STAT1 | activates | gene | 0.85 |
| APOPTOSIS | activates | gene | 0.85 |
| INFLAMMATION | implicated_in | gene | 0.85 |
| AUTOPHAGY | activates | gene | 0.85 |
| SIRT1 | activates | gene | 0.85 |
| PYROPTOSIS | activates | gene | 0.85 |
| CYTOKINES | treats | gene | 0.85 |
| ERK | inhibits | gene | 0.85 |
| OXIDATIVE STRESS | inhibits | gene | 0.85 |
| GPX4 | activates | gene | 0.85 |
| FERROPTOSIS | activates | gene | 0.85 |
| AUTOPHAGY | associated_with | gene | 0.85 |
| Pericyte-derived Extracellular Vesicles | treats | organelle | 0.85 |
| FGF21 | treats | protein | 0.85 |
| CRP | biomarker_for | biomarker | 0.85 |
| Procalcitonin | biomarker_for | biomarker | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||