| Gene Symbol | ABCG2 |
| Full Name | ATP Binding Cassette Subfamily G Member 2 |
| Chromosome | 4q22.1 |
| Protein Type | Transporter |
| Function | encodes a 72 kDa half-transporter that functions as a homodimer at the blood-brain barrier. |
| Molecular Weight | 72 kDa |
| Exons | 16 |
| Pathways | Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle |
| Ensembl ID | ENSG00000118777 |
| GeneCards | ABCG2 |
| Human Protein Atlas | ABCG2 |
| Homodimeric architecture | Two ABCG2 monomers assemble via extensive TMD interactions to form a functional transporter with a central drug-binding cavity |
| Substrate specificity | Preferentially transports sulfated and glucuronidated conjugates, porphyrins, dietary flavonoids, urate, and various chemotherapeutic agents |
| Cooperative transport | Some substrates show positive cooperativity, with binding at one site enhancing transport at the other |
| Associated Diseases | Alzheimer, Alzheimer's disease, Anxiety, Dementia, Depression |
| Interactions | ABCB1, AKT, AMPK, AND, ATP, AUTOPHAGY |
| KG Connections | 237 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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