Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Circadian clock / BMAL1-CLOCK transcription: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| BMAL1 | participates_in | gene | 0.46 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian Rhythm Entrainment of Reactive Astrocytes | 0.722 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Circadian-Metabolic Microglial Reprogramming | 0.662 | - | Neuroinflammation and microglial priming |
| Temporal Gating of Microglial Responses | 0.565 | alzheimers | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.741
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Circadian gene expression effects of SD vs ketamine | exploratory | depression | 0.950 | 0.00 | C57BL/6J mice | proposed | N/A |
| CLOCK/BMAL1 regulation of ICC autophagy in GERD model | exploratory | gastroesophageal reflux diseas | 0.900 | 0.00 | primary esophageal interstitia | proposed | N/A |
| Transcriptomic profiling and differential expression analysis | exploratory | Alzheimer's disease | 0.900 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
| qPCR and western blot analysis of microvascular functional molecules | exploratory | Alzheimer's disease | 0.850 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| Cell-cell interaction analysis of perivascular-microglial crosstalk | exploratory | Alzheimer's disease | 0.800 | 0.00 | AD mouse models | proposed | N/A |
| Morphological characterization of microglial states in human brain | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168] | Ruan W, Li T, Bang IH, Lee J, Deng W, Ma | Nature | 2025 | 1 |
| Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923] | Fernandes M, Liguori C | Handb Clin Neurol | 2025 | 1 |
| Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504] | Hussain Y, Dar MI, Pan X | Metabolites | 2024 | 1 |
| Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017] | Zeng Y, Guo Z, Wu M, Chen F, Chen L | Cell Death Discov | 2024 | 1 |
| Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594] | Pan X, Mota S, Zhang B | Adv Exp Med Biol | 2020 | 1 |
| BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150] | Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa | Biochemistry and biophysics re | 2026 | 0 |
| The mPFC molecular clock mediates the effects of sleep deprivation on depression [PMID:41023421] | Gardner W, Sarrazin DH, Balzinger M, Mar | Mol Psychiatry | 2026 | 0 |
| Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646] | Lin L, Liang X, Xu Z, Li Y, Guo Z et al. | Biomaterials | 2026 | 0 |
| Influence of sleep duration on cumulative genetic effects on obesity and related [PMID:41205781] | Zhang M, Lin J, Liu S, Jiang Y, Meng M e | Gene | 2026 | 0 |
| Clock gene influences on sleep quality and HPA axis in major depressive disorder [PMID:41429085] | Ferrer A, Pelegrí A, Labad J, Sagués T, | Sleep Med | 2026 | 0 |
| Acute heat stress reprograms the circadian-inflammatory-metabolic axis in Lasiop [PMID:41443385] | Wang XZ, Li Y, Wang CZ, Wang ZS, Zhang X | Comp Biochem Physiol C Toxicol | 2026 | 0 |
| The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525] | Sica V, Sato T, Tsialtas I, Hernandez S, | J Biol Rhythms | 2026 | 0 |
| Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008] | Tsameret S, Froy O, Matz Y, Landau Z, Tw | Diabetologia | 2026 | 0 |
| Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773] | He M, Sun Y, Tang C, Huang F, Zhu Z et a | Arterioscler Thromb Vasc Biol | 2026 | 0 |
| Light-at-night exposure drives myopia via melanopsin signalling. [PMID:41772203] | Li J, Li C, Wang M, Meng J, Dang J et al | Sci China Life Sci | 2026 | 0 |
| Circadian reprogramming by timed sodium intake reveals transcriptional pathways [PMID:41824567] | Torimitsu T, Kinouchi K, Changizi Ashtia | Sci Adv | 2026 | 0 |
| Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis b [PMID:41833677] | Wu X, Zhang Q, Wang QQ, Liu ZN, Ni YY et | Int J Biol Macromol | 2026 | 0 |
| Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987] | Al Saeedy DY, Hawkins E, Dozmorov MG, Tr | J Mol Neurosci | 2026 | 0 |
| A role for the cholinergic neuron circadian clock in RNA metabolism and mediatin [PMID:41397872] | Tam SB, Waldeck NJ, Wright M, Mojsilovic | Life science alliance | 2026 | 0 |
| Circadian disruption and its clinical implications in Parkinson's disease: A Nar [PMID:41905255] | Kataoka H, Saeki K, Sugie K, Obayashi K | Sleep medicine | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Circadian clock / BMAL1-CLOCK transcription in their description or question text
No additional research found