protein

BMAL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMAL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1367Connections

1Hypotheses

7Analyses

50Outgoing

50Incoming

Summary

BMAL1 is a protein involved in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, ATHEROSCLEROSIS, Aging. Connected to 603 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BMAL1
Full Name	Aryl Hydrocarbon Receptor Nuclear Translocator-Like
Chromosome	11p15.3
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	BMAL1 is a bHLH-PAS transcription factor with critical functions
Mechanism of Action	Small molecule modulator of circadian transcription
Druggability	Low (0.34)
Clinical Stage	Phase I
Pathways	Akt, Apoptosis, Autophagy, CIRCADIAN_RHYTHM, Camp Signaling
UniProt ID	E9PL54
NCBI Gene ID	10518
Ensembl ID	ENSG00000141510
OMIM	602550
GeneCards	BMAL1
Human Protein Atlas	BMAL1
Associated Diseases	ALS, ALZHEIMER, ATHEROSCLEROSIS, Aging
Known Drugs/Compounds	SXD, nicotinamide, lithium
Interactions	CDK1, ADAMTS4, BCL2, CLOCK, BAG3, ARNT
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Circadian Rhythm Entrainment of Reactive Astrocyte
KG Connections	1363 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BMAL1 — AlphaFold E9PL54 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BMAL1["BMAL1"] -->|"regulates"| CIRCADIAN_RHYTHM["CIRCADIAN_RHYTHM"]
    BMAL1["BMAL1"] -.->|"inhibits"| DCM["DCM"]
    BMAL1["BMAL1"] -.->|"inhibits"| CARDIAC_HYPERTROPHY["CARDIAC_HYPERTROPHY"]
    BMAL1["BMAL1"] -.->|"inhibits"| DIASTOLIC_DYSFUNCTION["DIASTOLIC_DYSFUNCTION"]
    BMAL1["BMAL1"] -->|"expressed in"| CARDIOMYOCYTE["CARDIOMYOCYTE"]
    BMAL1["BMAL1"] -->|"interacts"| HIF2A["HIF2A"]
    SKELETAL_AGING["SKELETAL_AGING"] -.->|"inhibits"| BMAL1["BMAL1"]
    style BMAL1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (967)

Target	Relation	Type	Str
Circadian Clock	component_of	pathway	0.96
ConA-Induced Liver Injury	regulates	disease	0.95
METABOLIC HEALTH	regulates	entity	0.95
Endothelial Cell Cycle	regulates	process	0.95
Endothelial Cells	expressed_in	cell_type	0.95
astrocyte activation	inhibits	process	0.95
Myocardial Injury	modulates	phenotype	0.95
circadian rhythm	drives	process	0.95
Angiogenesis	regulates	process	0.95
Obesity	protects_against	disease	0.95
HIF1A	regulates	gene	0.90
VEGF	regulates	gene	0.90
chondrocyte proliferation	associated_with	phenotype	0.90
dietary fat absorption	associated_with	phenotype	0.90
Circadian Rhythms	involved_in	process	0.90
Cellular Metabolism	regulates	process	0.90
Circadian Rhythm Regulation	involved_in	process	0.90
Circadian Rhythm Disruption	involved_in	process	0.90
Glial Activation	modulates	process	0.90
Amyloid-Beta Deposition	modulates	process	0.90
HIF1A	interacts_with	entity	0.90
Astrocyte Activation	modulates	phenotype	0.90
SNCA Aggregation	regulates	phenotype	0.90
Tau Aggregation	regulates	phenotype	0.90
CDK1	upregulates	gene	0.90
Diabetic Cardiomyopathy	protects_against	disease	0.90
SERPINE1	upregulates	gene	0.90
Glioblastoma Growth	regulates	phenotype	0.90
Endothelial Cell Cycle Progression	mediates	process	0.90
Circadian Gene Expression	involved_in	process	0.90
Endothelial Cell Cycle	associated_with	process	0.90
tau aggregation	promotes	phenotype	0.90
alpha-synuclein aggregation	promotes	phenotype	0.90
Circadian Rhythm Regulation	regulates	process	0.90
Adiposity	regulates	phenotype	0.90
Body Weight	regulates	phenotype	0.90
Intestine	expressed_in	cell_type	0.90
CLOCK	co_mentioned_with	gene	0.90
DGAT2	activates	gene	0.90
HIF2A	associated_with	protein	0.90
EGLN2	inhibits	gene	0.90
CIRCADIAN RHYTHM	associated_with	gene	0.90
LIPID METABOLISM	regulates	entity	0.90
NEURODEGENERATION	associated_with	entity	0.90
SLEEP-WAKE CYCLE	regulates	entity	0.90
Angiogenesis	involved_in	process	0.90
CCNA1	upregulates	gene	0.90
Circadian Rhythm	involved_in	process	0.90
HIF2A	forms_heterodimer_with	gene	0.90
neural stem cells	activates	cell_type	0.90

Incoming (400)

Source	Relation	Type	Str
EXERCISE	inhibits	gene	0.95
Astrocytes	expressed_in	cell_type	0.95
CLOCK	interacts_with	gene	0.90
SQSTM1	inhibits	protein	0.90
DNMT1	inhibits	protein	0.90
Chronic Sleep Deprivation	causes	process	0.90
h-5706bbd7	targets_gene	hypothesis	0.90
h-de52344d	targets_gene	hypothesis	0.90
High Glucose and Palmitic Acid	downregulates	compound	0.85
OBSTRUCTIVE SLEEP APNEA SYNDROME	modulates	entity	0.85
Type 2 Diabetes	downregulates	disease	0.85
REV-ERBA	inhibits	gene	0.80
h-5706bbd7	targets	hypothesis	0.80
Obstructive Sleep Apnea Syndrome	modulates	disease	0.75
OSAS	modulates	disease	0.75
melatonin	regulates	drug	0.70
Amyloid beta	inhibits	protein	0.70
IL17A	inhibits	protein	0.70
DNMT1	regulates	protein	0.70
exercise	regulates	process	0.70
SXD	activates	drug	0.70
oxidative phosphorylation	regulates	pathway	0.70
Blue light exposure	inhibits	process	0.70
NPAS2	interacts_with	protein	0.70
PPARα	activates	protein	0.70
PER1	expressed_in	gene	0.70
CLOCK	co_expressed_with	gene	0.70
metformin	regulates	drug	0.70
PER	co_expressed_with	gene	0.70
ATG5	activates	gene	0.65
ATG7	activates	gene	0.65
nicotinamide	targets	drug	0.65
SKELETAL_AGING	inhibits	phenotype	0.64
BANG	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
CKB	inhibits	gene	0.60
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DAO	associated_with	gene	0.60
CRY1	regulates	gene	0.60
ATM	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
BCL2	inhibits	gene	0.60
ARNT	regulates	gene	0.60
BDNF	associated_with	gene	0.60
GRM4	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Rhythm Entrainment of Reactive Astrocytes	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (7)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168]	Ruan W, Li T, Bang IH, Lee J, Deng W, Ma	Nature	2025	1
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923]	Fernandes M, Liguori C	Handb Clin Neurol	2025	1
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504]	Hussain Y, Dar MI, Pan X	Metabolites	2024	1
Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017]	Zeng Y, Guo Z, Wu M, Chen F, Chen L	Cell Death Discov	2024	1
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594]	Pan X, Mota S, Zhang B	Adv Exp Med Biol	2020	1
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150]	Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa	Biochemistry and biophysics re	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0
Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773]	He M, Sun Y, Tang C, Huang F, Zhu Z et a	Arterioscler Thromb Vasc Biol	2026	0
Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis b [PMID:41833677]	Wu X, Zhang Q, Wang QQ, Liu ZN, Ni YY et	Int J Biol Macromol	2026	0
Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infecti [PMID:41927871]	Suga K, Koizumi H, Asano Y, Hamasaki S,	Scientific reports	2026	0
Impact of acute blue light irradiation on the molecular clock and markers associ [PMID:41944887]	Vibriani A, Chen X, Kajiwara S, Orihara	J Mol Med (Berl)	2026	0
The clock out of sync: Insights into circadian disruption in wake-up vs non-wake [PMID:41945262]	Zhang X, Chen Z, Gu S, Zhu YL, Yu L et a	Adv Clin Exp Med	2026	0
Circadian disruption and its clinical implications in Parkinson's disease: A Nar [PMID:41905255]	Kataoka H, Saeki K, Sugie K, Obayashi K	Sleep medicine	2026	0
The neuroprotective role of eugenol against glyphosate-induced toxicity in rats: [PMID:41922126]	Bolat İ, Alat Ö, Orhan B, Dereli E, Teki	Tissue & cell	2026	0
Circadian abnormalities, molecular clock gene and chronobiological treatment for [PMID:41913359]	Chakraborty S, Srivastava V	Chronobiology international	2026	0
The rhythm of decline: Circadian disruption in neurodegeneration. [PMID:41066745]	Singh J, Kumar D, Kaur J, Singh A	Journal of food and drug analy	2025	0
Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its [PMID:41440117]	Smirnova KV, Smirnova LP, Amstislavskaya	Brain sciences	2025	0
Pharmacological targeting of BMAL1 modulates circadian and immune pathways. [PMID:40133642]	Pu H, Bailey LC, Bauer LG, Voronkov M, B	Nature chemical biology	2025	0

BMAL1

Understanding Entity Pages

Summary

Wiki Pages (21)

BMAL1 (ARNTL) Gene

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

Circadian Rhythm in Neurodegeneration

NPAS3 Gene

NF-kB Signaling Pathway in Neurodegeneration

Pathway Diagram

Outgoing (967)

Incoming (400)

Targeting Hypotheses (1)

Mentioning Analyses (7)

Epigenetic reprogramming in aging neurons

Senescent cell clearance as neurodegeneration therapy

Sleep disruption as cause and consequence of neurodegeneration

Neuroinflammation resolution mechanisms and pro-resolving mediators

Digital biomarkers and AI-driven early detection of neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Related Papers (20)

BMAL1

Understanding Entity Pages

Summary

Wiki Pages (21)

BMAL1 (ARNTL) Gene

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

Circadian Rhythm in Neurodegeneration

NPAS3 Gene

NF-kB Signaling Pathway in Neurodegeneration

Transcriptional Regulation in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Circadian Rhythm Modulation Therapy

Sleep and Neurodegeneration

Type 3 Diabetes Hypothesis of Alzheimer's Disease

Sleep-Wake Cycle

Sleep Disruption in Alzheimer's Disease

Circadian Dysfunction Across Neurodegenerative Diseases

Sleep Architecture Changes in CBS and PSP

Circadian Rhythm Dysfunction in Alzheimer's Disease

sleep-disruption-neurodegeneration

Circadian Disruption in Neurodegeneration

Oxytocin Receptor Neurons

Chromatin Remodeling in Neurodegeneration

NF-κB Signaling in Neurodegeneration

Pathway Diagram

Outgoing (967)

Incoming (400)

Targeting Hypotheses (1)

Mentioning Analyses (7)

Epigenetic reprogramming in aging neurons

Senescent cell clearance as neurodegeneration therapy

Sleep disruption as cause and consequence of neurodegeneration

Neuroinflammation resolution mechanisms and pro-resolving mediators

Digital biomarkers and AI-driven early detection of neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Related Papers (20)