Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cytoplasmic Mislocalization: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TARDBP | associated_with | protein | 0.90 |
| FUS | associated_with | protein | 0.90 |
| FUS | involved_in | protein | 0.88 |
| RNA-Binding Proteins | involved_in | protein | 0.85 |
| TDP-43 | causes | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP-Secreted MMP-9 from Senescent Microglia Disrupts TDP-43 | 0.511 | als | What are the mechanisms by which microgl |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 18 hypotheses Top: 0.738
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells. [PMID:41000837] | Unknown | bioRxiv | 2025 | 0 |
| Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopat [PMID:34412701] | Unknown | Acta Neuropathol Commun | 2021 | 0 |
| Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP- [PMID:30458231] | Unknown | Neurobiology of disease | 2019 | 0 |
| TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synaps [PMID:28669544] | Unknown | Neuron | 2017 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.84 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-11
Hypotheses and analyses mentioning Cytoplasmic Mislocalization in their description or question text
No additional research found