Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ketone Utilization Index as Metabolic Flexibility Biomarker | 0.829 | translational-neuroscience | Which metabolic biomarkers can distingui |
| CSF/Plasma AQP4 Polarization Index as a Novel Biomarker of A | 0.705 | - | What blood-brain barrier permeability ch |
| TREM2-Driven Senescence Biomarker Index for Predicting Neuro | 0.642 | neurodegeneration | Gene expression changes in aging mouse b |
| Stratified falsifiers should govern Causal Discovery Benchma | 0.591 | neurodegeneration | Causal Discovery Benchmark: SciDEX vs LL |
| Multi-Biomarker Composite Index Surpassing Amyloid PET for T | 0.579 | neurodegeneration | Multi-modal Biomarker Panel Design for E |
| SciDEX debate-engine causal discovery benchmark should remai | 0.577 | neurodegeneration | Causal Discovery Benchmark: SciDEX vs LL |
| Multi-Modal Metabolic Connectivity Index for Disease Progres | 0.000 | - | Which metabolic biomarkers can distingui |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| AECII-specific HMGCS2 overexpression in mouse pulmonary fibrosis | validation | idiopathic pulmonary fibrosis | 0.950 | 0.00 | C57BL/6 mice with AECII-specif | proposed | N/A |
| Ketogenic diet fat threshold analysis in wild-type mice | validation | metabolic disease | 0.900 | 0.00 | C57BL/6J wild-type mice | proposed | N/A |
| HMGCS2 gain-of-function in AECII lipid metabolism regulation | exploratory | idiopathic pulmonary fibrosis | 0.900 | 0.00 | human AECIIs | proposed | N/A |
| Ketogenic diet efficacy in diet-induced obese mice | validation | obesity, metabolic disease | 0.900 | 0.00 | C57BL/6J diet-induced obese mi | proposed | N/A |
| Microarray and single-cell RNA analysis of lipid metabolism genes | exploratory | idiopathic pulmonary fibrosis | 0.850 | 0.00 | human patients, mouse models | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345] | Hussain R, Graham U, Elder A, Nedergaard | Trends in neurosciences | 2023 | 0 |
| Roles of neuropathology-associated reactive astrocytes: a systematic review. [PMID:36915214] | Lawrence JM, Schardien K, Wigdahl B, Non | Acta neuropathologica communic | 2023 | 0 |
| CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] | Guerreiro S, Privat AL, Bressac L, Toulo | Cells | 2020 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] | Guerreiro S, Privat AL, Bressac L, Toulo | Cells | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced m [PMID:29400714] | Shi Y, Lin S, Staats KA, Li Y, Chang WH, | Nature medicine | 2018 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning DEX in their description or question text
Score: 0.577 · neurodegeneration · 2026-04-28
The consensus is to preserve this as a debated candidate, not a canonical world-model claim. Replication or rerun eviden
Score: 0.000 · unknown disease · 2026-04-28
Combine metabolic PET imaging with functional connectivity MRI to create a metabolic connectivity index measuring coordi