gene

DHH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

2Hypotheses

0Analyses

0Outgoing

0Incoming

1Experiments

0Debates

Summary

Page for DHH — Desert Hedgehog

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🧬 Gene Info

Gene Symbol	DHH
Full Name	Desert Hedgehog
Chromosome	12q13.12
Function	is a member of the Hedgehog signaling family with specialized roles in male gonad development, peripheral nerve myelination, and steroidogenesis.
Molecular Weight	19 kDa
Amino Acids	396 aa
Exons	3
Ensembl ID	ENSG00000104970
GeneCards	DHH
Human Protein Atlas	DHH
Receptor binding	DHH binds PTCH1 (Patched-1) receptor
SMO activation	Relief of SMO (Smoothened) inhibition
GLI activation	GLI transcription factors activated
Target genes	GLI1, GLI2, PTCH1, HHIP, BMP
Leydig cell differentiation	DHH from Sertoli cells induces Leydig cell development
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

DHH — Desert Hedgehog

gene · 873 words

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Validated Hypothesis: Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization

hypothesis · 5313 words

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Pathway Diagram

graph TD
    DHH["DHH"]
    neurodegeneration["neurodegeneration"]
    DHH -->|"implicated_in"| neurodegeneration
    style DHH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.885	alzheimers	Circuit-level neural dynamics in neurode
Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabiliz	0.580	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Synaptic plasticity and protein expression analysis in mPFC	exploratory	insomnia-anxiety comorbidity	0.850	0.00	mPFC brain slices from PCPA-tr	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DHH in their description or question text

No additional research found

DHH