Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLGAP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DLGAP4 (Discs Large Homolog Associated Protein 4) is a synaptic scaffolding protein critical for postsynaptic density organization, synapse function, and neuronal signaling in neurodegenerative diseases.
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| Gene Symbol | DLGAP4 |
| Aliases | Discs Large Homolog Associated Protein 4 |
| Chromosome | 8q24.3 |
| Function | DLGAP4 is a member of the SAPAP family of postsynaptic density proteins. |
| Primary Expression | various brain regions including the hippocampus and cortex |
| Molecular Weight | 103 kDa |
| Amino Acids | 977 aa |
| Exons | 25 |
| UniProt ID | O75181 |
| NCBI Gene ID | 22858 |
| Ensembl ID | ENSG00000159788 |
| GeneCards | DLGAP4 |
| Human Protein Atlas | DLGAP4 |
| Autism Spectrum Disorder | Rare variants in DLGAP4 have been identified in patients with ASD. |
| Intellectual Disability | Loss-of-function mutations contribute to intellectual disability phenotypes. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DLGAP4["DLGAP4"]
neurodegeneration["neurodegeneration"]
DLGAP4 -->|"implicated_in"| neurodegeneration
style DLGAP4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DLGAP4 in their description or question text
No additional research found