Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJB7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DNAJB7 is a DnaJ/Hsp40 family molecular chaperone involved in protein folding, quality control, and clearance of protein aggregates. Linked to autism spectrum disorder and neurodevelopmental disorders.
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| Gene Symbol | DNAJB7 |
| Chromosome | 5q31.3 |
| Protein Type | Gene |
| Function | The coordinated action of Hsp40 co-chaperones like DNAJB7 with Hsp70 chaperones ensures proper protein folding through several mechanisms |
| Primary Expression | various tissues, with notably high expression in testis and lower but significant expression in brain regions [@Qiu2006] |
| Molecular Weight | 28 kDa |
| Amino Acids | 257 aa |
| Exons | 4 |
| Ensembl ID | ENSG00000166685 |
| GeneCards | DNAJB7 |
| Human Protein Atlas | DNAJB7 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJB7["DNAJB7"]
neurodegeneration["neurodegeneration"]
DNAJB7 -->|"implicated_in"| neurodegeneration
style DNAJB7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DNAJB7 in their description or question text
No additional research found