gene

DNM3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DNM3 (Dynamin 3) is a brain-specific GTPase critical for synaptic vesicle endocytosis, dendritic spine morphogenesis, and postsynaptic receptor trafficking. Implicated in Alzheimer's disease, Parkinson's disease, intellectual disability, and schizophrenia.

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🧬 Gene Info

Gene Symbol	DNM3
Full Name	Dynamin 3
Chromosome	1p31.1
Protein Type	GTPase (mechanochemical enzyme)
Function	encodes a brain-specific GTPase that plays critical roles in synaptic vesicle endocytosis, dendritic spine morphogenesis, and postsynaptic receptor trafficking.
Primary Expression	Brain-specific
Subcellular Localization	Dendritic spines, postsynaptic densities, and dendritic shafts
Molecular Weight	96 kDa
Amino Acids	864 aa
UniProt ID	Q9UQ16
NCBI Gene ID	27037
Ensembl ID	ENSG00000197933
OMIM	611347
GeneCards	DNM3
Human Protein Atlas	DNM3
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DNM3 — AlphaFold Q9UQ16 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNM3 — Dynamin 3

gene · 1380 words

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Pathway Diagram

graph TD
    DNM3["DNM3"]
    neurodegeneration["neurodegeneration"]
    DNM3 -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    DNM3 -->|"implicated in"| Alzheimer_S_Disease
    Parkinson_S_Disease{"Parkinson'S Disease"}
    DNM3 -->|"implicated in"| Parkinson_S_Disease
    Schizophrenia{"Schizophrenia"}
    DNM3 -->|"implicated in"| Schizophrenia
    Endocytosis(["Endocytosis"])
    DNM3 -->|"regulates"| Endocytosis
    Synaptic_Vesicle(["Synaptic Vesicle"])
    DNM3 -->|"regulates"| Synaptic_Vesicle
    style DNM3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Schizophrenia fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Synaptic_Vesicle fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Endocytosis fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DNM3 in their description or question text

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