Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about E2F6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
E2F6 encodes a transcription factor that regulates cell cycle progression and has implications in neurodegeneration
| Gene Symbol | E2F6 |
| Full Name | E2F Transcription Factor 6 |
| Chromosome | 2p25.1. |
| Protein Family | E2F transcription factor family |
| Protein Type | Transcription Factor |
| Function | is a member of the E2F family of transcription factors that play critical roles in regulating cell cycle progression, gene expression, and cellular differentiation. |
| Primary Expression | human tissues, with highest expression in the brain, testes, and embryonic tissues |
| Molecular Weight | 31.7 kDa |
| Amino Acids | 294 aa |
| UniProt ID | O75141 |
| NCBI Gene ID | 1876 |
| Ensembl ID | ENSG00000169081 |
| OMIM | 602944 |
| GeneCards | E2F6 |
| Human Protein Atlas | E2F6 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
E2F6["E2F6"]
neurodegeneration["neurodegeneration"]
E2F6 -->|"implicated_in"| neurodegeneration
style E2F6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||