protein

HIF-1Α

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF-1Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

497Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

HIF-1Α is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with ALS, Aging, Cancer. Connected to 63 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HIF
GeneCards	HIF
Human Protein Atlas	HIF
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	quercetin, rapamycin
Interactions	ABCD3, AGING, AKK, AKT, AKT1, ALS
KG Connections	1341 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    HIF_1_["HIF-1Alpha"]
    Carcinoma{"Carcinoma"}
    HIF_1_ -->|"activates"| Carcinoma
    ALS{"ALS"}
    HIF_1_ -->|"activates"| ALS
    Cancer{"Cancer"}
    HIF_1_ -->|"activates"| Cancer
    Tumor{"Tumor"}
    HIF_1_ -->|"activates"| Tumor
    Inflammation{"Inflammation"}
    HIF_1_ -->|"activates"| Inflammation
    Aging{"Aging"}
    HIF_1_ -->|"activates"| Aging
    Glycolysis(["Glycolysis"])
    HIF_1_ -->|"activates"| Glycolysis
    PI3K["PI3K"]
    HIF_1_ -->|"activates"| PI3K
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    HIF_1_ -->|"activates"| Oxidative_Phosphorylation
    Mtor(["Mtor"])
    HIF_1_ -->|"activates"| Mtor
    Pi3K_Akt(["Pi3K/Akt"])
    HIF_1_ -->|"activates"| Pi3K_Akt
    LDHA["LDHA"]
    HIF_1_ -->|"activates"| LDHA
    IDH2["IDH2"]
    IDH2 -->|"activates"| HIF_1_
    HIF["HIF"]
    HIF -->|"activates"| HIF_1_
    AND["AND"]
    AND -->|"activates"| HIF_1_
    GAIN["GAIN"]
    GAIN -->|"activates"| HIF_1_
    TKT["TKT"]
    TKT -->|"activates"| HIF_1_
    TIGAR["TIGAR"]
    TIGAR -->|"activates"| HIF_1_
    CANCER["CANCER"]
    CANCER -->|"activates"| HIF_1_
    MYC["MYC"]
    MYC -->|"activates"| HIF_1_
    HK2["HK2"]
    HK2 -->|"activates"| HIF_1_
    AKT["AKT"]
    AKT -->|"activates"| HIF_1_
    MTORC1["MTORC1"]
    MTORC1 -->|"activates"| HIF_1_
    PI3K -->|"activates"| HIF_1_
    style HIF_1_ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (355)

Target	Relation	Type	Str
Glycolysis	upregulates	process	0.95
ESM1	regulates	protein	0.95
VIMENTIN	upregulates	gene	0.90
TGFB1	upregulates	gene	0.90
Aerobic Glycolysis	upregulates	pathway	0.90
Metabolic Reprogramming	associated_with	process	0.85
VEGFA	upregulates	protein	0.85
Proinflammatory Macrophage Activation	activates	process	0.85
Microglial Function	regulates	process	0.85
GLYCOLYSIS	upregulates	process	0.80
microglial metabolism	regulates	process	0.80
neurodegenerative diseases	implicated_in	disease	0.80
ferroptosis	regulates	process	0.70
microglial function	regulates	process	0.70
oxygen tension	independent_of	process	0.70
Glioblastoma	activates	disease	0.65
Ischemia	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Lymphoma	inhibits	disease	0.65
Covid	inhibits	disease	0.65
Als	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Depression	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Aging	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Melanoma	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Sepsis	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
ALS	regulates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65

Incoming (142)

Source	Relation	Type	Str
Autophagy	downregulates	process	0.90
Sympathetic Activation	upregulates	process	0.90
Wnt Signaling Pathway	activates	pathway	0.90
PI3K/Akt Pathway	regulates	pathway	0.85
FGF21	modulates	protein	0.85
Reductive Glutamine Metabolism	associated_with	process	0.85
PIEZO1	regulates	gene	0.85
PI3K/Akt Pathway	regulates	pathway	0.85
EIF4G2	regulates	gene	0.80
EEF2	inhibits	gene	0.80
SIMA	homolog_of	gene	0.80
IDH2	stabilizes	gene	0.80
VCP	stabilizes	gene	0.70
STAT3	activates	protein	0.70
AKT	activates	gene	0.60
MTORC1	activates	gene	0.60
PI3K	activates	gene	0.60
MTOR	activates	gene	0.60
SRC	activates	gene	0.60
GENES	activates	gene	0.60
HK1	activates	gene	0.60
AMPK	activates	gene	0.60
G6PD	activates	gene	0.60
FASN	activates	gene	0.60
LDHB	activates	gene	0.60
PTEN	activates	gene	0.60
NAD	activates	gene	0.60
AGING	activates	gene	0.60
SLC7A11	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
MITOCHONDRIAL DNA	inhibits	gene	0.60
DNA	inhibits	gene	0.60
FOXO3	inhibits	gene	0.60
MTDNA	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
INFLAMMATION	regulates	gene	0.60
NLRP3	inhibits	gene	0.60
INFLAMMATION	associated_with	gene	0.60
JAK	regulates	gene	0.60
CIRCADIAN CLOCK GENES	regulates	gene	0.60
GBM	inhibits	gene	0.60
PKM	activates	gene	0.60
LDHA	activates	gene	0.60
GLUT1	activates	gene	0.60
GLUT3	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
LPL	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Targeting SASP-Complement Amplification Through HIF-1α Downs	0.793	neurodegeneration	What molecular mechanism causes VCP muta
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.793

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	0.00	Human atherosclerotic plaque s	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflamma [PMID:38342616]	Ambrin G, Kang YJ, Van Do K, Lee C, Sing	Advanced science (Weinheim, Ba	2024
A molecular switch for neuroprotective astrocyte reactivity. [PMID:38086421]	Cameron EG, Nahmou M, Toth AB, Heo L, Ta	Nature	2024
TREM2 receptor protects against complement-mediated synaptic loss by binding to [PMID:37442133]	Zhong L, Sheng X, Wang W, Li Y, Zhuo R,	Immunity	2023
Roles of neuropathology-associated reactive astrocytes: a systematic review. [PMID:36915214]	Lawrence JM, Schardien K, Wigdahl B, Non	Acta neuropathologica communic	2023
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. [PMID:32866962]	Zhang J, Velmeshev D, Hashimoto K, Huang	Nature	2020

Debates (1)

Multi-agent debates referencing this entity

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

closed · Rounds: 4 · Score: 0.78 · 2026-04-13

Related Research

Hypotheses and analyses mentioning HIF-1Α in their description or question text

No additional research found