entity

GR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

30Hypotheses

30Analyses

50Outgoing

26Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (53)

Target	Relation	Type	Str
Glioblastoma	regulates	disease	0.95
Memory Impairment	mediates	phenotype	0.85
Ferroptosis	protects_against	process	0.85
Microglial Activation	regulates	process	0.80
Glutamate Excitotoxicity	contributes_to	process	0.75
Oxidative Stress	contributes_to	process	0.75
HPA_AXIS	regulates	pathway	0.72
frontotemporal dementia	associated_with	disease	0.70
TUMOR_GROWTH	regulates	phenotype	0.64
P38	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
TNF	activates	gene	0.60
NLRP3	inhibits	gene	0.60
neurodegeneration	regulates	disease	0.60
neurodegeneration	activates	disease	0.60
HSP70	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
HSPA8	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
STUB1	regulates	gene	0.60
VCP	regulates	gene	0.60
NQO1	inhibits	gene	0.60
ferroptosis	participates_in	pathway	0.60
SRRM2	associated_with	gene	0.60
NR3C1	regulates	gene	0.60
NR3C1	associated_with	gene	0.60
NFL	expressed_in	gene	0.60
neurodegeneration	expressed_in	disease	0.60
NFL	causes	gene	0.60
neurodegeneration	associated_with	disease	0.60
LDH	biomarker_for	gene	0.60
neuroinflammation	inhibits	disease	0.60
LC3	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
pyroptosis	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
frontotemporal dementia	activates	disease	0.60
HSC70	regulates	gene	0.60
glioblastoma	activates	disease	0.60
glioblastoma	expressed_in	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
NAD	inhibits	gene	0.60
CRISPR-Cas	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
ROS	activates	gene	0.60
NR3C2	associated_with	gene	0.60
RNA	activates	gene	0.60
GSH	biomarker_for	gene	0.60

Incoming (26)

Source	Relation	Type	Str
Mifepristone	inhibits	drug	0.95
RU486	inhibits	drug	0.95
Corticosterone	activates	compound	0.85
EIF4G2	interacts_with	gene	0.80
FERROPTOSIS	inhibits	process	0.80
ALS	associated_with	gene	0.70
DNA	activates	gene	0.70
SKA2	regulates	gene	0.64
C9ORF72	interacts_with	gene	0.60
AKT	activates	gene	0.60
GCLC	activates	gene	0.60
BAG3	regulates	gene	0.60
CALR	regulates	gene	0.60
BDNF	expressed_in	gene	0.60
BDNF	regulates	gene	0.60
BDNF	activates	gene	0.60
GBM	activates	gene	0.60
GBM	expressed_in	gene	0.60
FSP1	inhibits	gene	0.60
AR	inhibits	gene	0.60
BECN1	associated_with	gene	0.60
ALS	activates	gene	0.60
DHFR	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
AGER	associated_with	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
STMN2 Restoration as a Prerequisite for Axon Growth After TD	0.658	neurodegeneration	What molecular mechanisms enable functio
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Integrated Biomarker Panel for Therapeutic Window Identifica	0.615	neurodegeneration	What are the precise temporal dynamics o
Digital Twin-Guided Metabolic Reprogramming	0.605	neurodegeneration	Digital biomarkers and AI-driven early d

IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.595	neurodegeneration	APOE4 structural biology and therapeutic
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.589	neurodegeneration	Gene expression changes in aging mouse b
GDNF Gradient Establishment by Schwann Cells Enables Motor R	0.585	neurodegeneration	What molecular mechanisms enable functio
TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neur	0.584	neurodegeneration	What are the specific molecular mechanis
Synthetic Biology BBB Endothelial Cell Reprogramming	0.565	neurodegeneration	Blood-brain barrier transport mechanisms
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.559	neurodegeneration	How does PIKFYVE inhibition activate unc
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Heterogeneous astrocyte activation states differentially imp	0.523	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat	0.517	neurodegeneration	CRISPR-based therapeutic approaches for
Membrane Cholesterol Gradient Modulators	0.517	neurodegeneration	Lipid raft composition changes in synapt
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.514	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
Heat Shock Protein 70 Disaggregase Amplification	0.511	neurodegeneration	TDP-43 phase separation therapeutics for
Epigenetic Reprogramming of Microglial Memory	0.508	Alzheimer's disease	Neuroinflammation and microglial priming
Mechanosensitive Ion Channel Reprogramming	0.505	neurodegeneration	Astrocyte reactivity subtypes in neurode
Disease-Associated Microglia Metabolic Reprogramming	0.502	neurodegeneration	Cell type vulnerability in Alzheimers Di
Stress Granule Phase Separation Modulators	0.490	neurodegeneration	RNA binding protein dysregulation across
EV-Mediated Epigenetic Reprogramming	0.490	neurodegeneration	Extracellular vesicle biomarkers for ear
EV-Mediated Epigenetic Reprogramming	0.486	neurodegeneration	Extracellular vesicle biomarkers for ear
Microglial Purinergic Reprogramming	0.483	neurodegeneration	4R-tau strain-specific spreading pattern
RNA Granule Nucleation Site Modulation	0.479	neurodegeneration	TDP-43 phase separation therapeutics for
Astrocyte Metabolic Memory Reprogramming	0.478	neurodegeneration	How do astrocyte-neuron metabolic intera
TFAM overexpression creates mitochondrial donor-recipient gr	0.474	neurodegeneration	Mitochondrial transfer between astrocyte
Cell-Type Specific Metabolic Reprogramming	0.471	neurodegeneration	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (30)

Scientific analyses that reference this entity

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285]	Fang M, Zhou Y, He K, Lu Y, Tao F, Huang	Mol Neurobiol	2025	1
Metformin restores mitochondrial bioenergetics and redox homeostasis through mod [PMID:40327990]	Brondani M, Ribeiro RT, Pinheiro CV, Hof	Biomed Pharmacother	2025	1
System biology-based assessment of the molecular mechanism of epigallocatechin g [PMID:40664965]	Fanai HL, Chand J, Ahmad SF, Attia SM, E	Sci Rep	2025	1
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685]	Litvinchuk A, Suh JH, Guo JL, Lin K, Dav	Neuron	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216]	Banik SM, Pedram K, Wisnovsky S, Ahn G,	Nature	2020	1
Minutes of PPAR-γ agonism and neuroprotection. [PMID:32758586]	Prashantha Kumar BR, Kumar AP, Jose JA,	Neurochem Int	2020	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
The pharmacogenetics of type 2 diabetes: a systematic review. [PMID:24558078]	Nisa M Maruthur, Matthew O Gribble, Wend	Diabetes care	2014	1
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188]	Cetindag AC, Schipke CG, Esselmann H, Kr	The journal of prevention of A	2026	0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963]	Zhu L, Du L, Wu J, Ding D, Wang J et al.	J Invest Dermatol	2026	0
Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204]	Sang Y, Cao Y, Li S, Quan Y, Wang S et a	Biomaterials	2026	0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196]	Lin Z, Xiong J, Zhang F, Zhang H, Zhu M	Mol Ther	2026	0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227]	Samudra N, Vemuri M, Weitlauf J	Curr Opin Obstet Gynecol	2026	0

GR

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

nhp-validation-animal-model

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Oligodendrocytes

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Microglial Senescence Pathway in Neurodegeneration

er-stress-neurodegeneration

ALS-FTD Spectrum

JAK-STAT Signaling Pathway in Neurodegeneration

Mitochondrial Dysfunction in Progressive Supranuclear Palsy

HPA Axis Dysfunction in Neurodegeneration

Trinucleotide Repeat Expansion Disorders

TREM2 in Frontotemporal Dementia

Glucocorticoid Signaling Pathway in Neurodegeneration

PNMT Protein

CORT108297 Phase 2 (NCT04601038) - Stress Attenuation in AD

cortisol-tau-pathway

Reactive Oxygen Species (ROS) Pathway

ALS Biomarker-to-Mechanism Mapping

Outgoing (53)

Incoming (26)

Targeting Hypotheses (30)

Mentioning Analyses (30)

What are the specific molecular determinants that govern tau strain selection du

Are age-related static epigenetic patterns pathogenic or protective compensatory

What is the temporal sequence of TREM2 signaling transition from protective to i

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

How does pericyte senescence mechanistically promote glioma cell growth and inva

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why do TAM receptors protect against neuroinvasive viruses despite their known i

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

What is the atomic-resolution structure of K280-acetylated tau and how does it t

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

What determines the temporal transition from protective to pathological stress g

What are the molecular determinants that control directional mitochondrial trans

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

Do tau aggregates represent protective responses or primary pathogenic drivers i

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Do chronic stress granule inhibition strategies impair normal cellular stress re

What brain concentrations of SCFAs are achieved via oral probiotics and are they

Do migratory animals encode specific spatial locations epigenetically or rely on

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

What are the specific design principles for small molecules that can selectively

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Related Papers (20)