concept

GR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections

30Hypotheses

1Analyses

50Outgoing

26Incoming

10Experiments

1Debates

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💡 Concept Info

Name	GR
Key Genes/Proteins	AGER, AKT, ALS, AR, BAG3, BDNF
Related Diseases	Alzheimer's disease
Related Pathways	apoptosis pathway, autophagy pathway, CRISPR-Cas
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GR[GR]
    GR -->|regulates| Glioblastoma[Glioblastoma]
    GR -->|mediates| Memory_Impairment[Memory Impairment]
    GR -.protects against.-> Ferroptosis[Ferroptosis]
    GR -->|regulates| Microglial_Activation[Microglial Activation]
    GR -->|contributes to| Glutamate_Excitotoxicity[Glutamate Excitotoxicity]
    GR -->|contributes to| Oxidative_Stress[Oxidative Stress]
    GR -->|regulates| HPA_AXIS[HPA_AXIS]
    GR -->|regulates| TUMOR_GROWTH[TUMOR_GROWTH]
    GR -->|interacts| P38[P38]
    GR -->|activates| NLRP3[NLRP3]
    Mifepristone[Mifepristone] -->|inhibits| GR
    RU486[RU486] -->|inhibits| GR
    Corticosterone[Corticosterone] -->|activates| GR
    EIF4G2[EIF4G2] -->|interacts| GR
    FERROPTOSIS[FERROPTOSIS] -->|inhibits| GR
    DNA[DNA] -->|activates| GR
    SKA2[SKA2] -->|regulates| GR
    C9ORF72[C9ORF72] -->|interacts| GR
    AKT[AKT] -->|activates| GR
    GCLC[GCLC] -->|activates| GR

Outgoing (54)

Target	Relation	Type	Str
Glioblastoma	regulates	disease	0.95
Memory Impairment	mediates	phenotype	0.85
Ferroptosis	protects_against	process	0.85
Microglial Activation	regulates	process	0.80
Glutamate Excitotoxicity	contributes_to	process	0.75
Oxidative Stress	contributes_to	process	0.75
HPA_AXIS	regulates	pathway	0.72
frontotemporal dementia	associated_with	disease	0.70
stress_reduction_interventions	therapeutic_target_for	intervention	0.70
TUMOR_GROWTH	regulates	phenotype	0.64
CRISPR-Cas	participates_in	pathway	0.60
glioblastoma	activates	disease	0.60
glioblastoma	expressed_in	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
NAD	inhibits	gene	0.60
LDH	biomarker_for	gene	0.60
LC3	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
microglia	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
ROS	activates	gene	0.60
NR3C2	associated_with	gene	0.60
neurodegeneration	regulates	disease	0.60
RNA	activates	gene	0.60
SQSTM1	regulates	gene	0.60
STUB1	regulates	gene	0.60
VCP	regulates	gene	0.60
pyroptosis	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
HSPA8	regulates	gene	0.60
P38	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
TNF	activates	gene	0.60
NLRP3	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
ferroptosis	participates_in	pathway	0.60
SRRM2	associated_with	gene	0.60
NR3C1	regulates	gene	0.60
HSP70	regulates	gene	0.60
NFL	expressed_in	gene	0.60
neurodegeneration	expressed_in	disease	0.60
NFL	causes	gene	0.60
neurodegeneration	associated_with	disease	0.60
neuroinflammation	inhibits	disease	0.60
frontotemporal dementia	activates	disease	0.60
HSC70	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
NR3C1	associated_with	gene	0.60
HSPA1A	regulates	gene	0.60

Incoming (26)

Source	Relation	Type	Str
RU486	inhibits	drug	0.95
Mifepristone	inhibits	drug	0.95
Corticosterone	activates	compound	0.85
FERROPTOSIS	inhibits	process	0.80
EIF4G2	interacts_with	gene	0.80
ALS	associated_with	gene	0.70
DNA	activates	gene	0.70
SKA2	regulates	gene	0.64
BECN1	associated_with	gene	0.60
BAG3	regulates	gene	0.60
CALR	regulates	gene	0.60
DNA	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
BDNF	expressed_in	gene	0.60
BDNF	regulates	gene	0.60
BDNF	activates	gene	0.60
GBM	activates	gene	0.60
GBM	expressed_in	gene	0.60
FSP1	inhibits	gene	0.60
AR	inhibits	gene	0.60
ALS	activates	gene	0.60
GCLC	activates	gene	0.60
C9ORF72	interacts_with	gene	0.60
AKT	activates	gene	0.60
DHFR	inhibits	gene	0.60
AGER	associated_with	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
eIF2α Phosphorylation Imbalance Creates Integrated Stress Re	0.896	als	-
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P	0.868	als	-
hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport F	0.851	als	-
Elevated CSF/Serum Albumin Quotient Predicts Neurodegenerati	0.850	-	What blood-brain barrier permeability ch
J-protein co-chaperone system mediates selective autophagy t	0.831	protein-biochemistry	Do chaperones selectively recognize path

Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.822	neurodegeneration	What are the mechanisms by which gut mic
TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress	0.810	als	-
Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2,	0.807	biomarkers	What biomarkers can reliably detect micr
TREM2-mTOR Co-Agonism for Metabolic Reprogramming	0.803	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.795	neurodegeneration	APOE4 structural biology and therapeutic
Integrated Biomarker Panel for Therapeutic Window Identifica	0.784	neurodegeneration	What are the precise temporal dynamics o
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
Stress-granule RNA-binding protein phase transition across A	0.780	multi	Cross-disease neurodegeneration mechanis
Exosomal SNCA Propagation from Lysosome-Compromised Neurons	0.777	neurodegeneration	-
CX3CR1-TREM2 Integration for Synapse Pruning Normalization	0.776	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
Gamma entrainment induces activity-dependent BDNF release to	0.773	alzheimers	Gamma entrainment therapy to restore hip
GRN/progranulin lysosomal insufficiency across FTD, ALS-spec	0.756	multi	Cross-disease neurodegeneration mechanis
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.748	neurodegeneration	Gene expression changes in aging mouse b
GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Si	0.747	neurodegeneration	-
H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Gran	0.737	neurodegeneration	How do pathological stress granules tran
Metabolic Inflexibility Precedes Transcriptional Reprogrammi	0.735	neurodegeneration	What is the optimal therapeutic window f
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.734	neurodegeneration	What molecular mechanisms link elevated
Synthetic Biology BBB Endothelial Cell Reprogramming	0.727	neurodegeneration	Blood-brain barrier transport mechanisms
TFAM overexpression creates mitochondrial donor-recipient gr	0.725	neurodegeneration	Mitochondrial transfer between astrocyte
Metabolic Reprogramming to Reverse Senescence	0.720	-	Senescent cell clearance as neurodegener
Stress Granule Phase Separation Modulators	0.720	neurodegeneration	RNA binding protein dysregulation across
C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Gra	0.717	neurodegeneration	How do pathological stress granules in n
EZH2-Mediated H3K27me3 Spreading in Senescent ALS Microglia	0.714	als	What are the mechanisms by which microgl
Liquid-to-Solid Transition Pathology Reveals Granule Weak Po	0.712	neurodegeneration	What determines the specificity of RNA-p
TBK1 Loss Triggers eIF2α-Mediated Translational Repression T	0.000	als	What are the mechanisms by which microgl

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.756

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
GWAS of plasma NfL in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma pTau217 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
Dairy intake and dementia risk in Malmö Diet and Cancer cohort	clinical	Alzheimer's disease	0.950	0.00	Swedish community-based adults	proposed	N/A
GWAS of plasma pTau181 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma GFAP in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
KEEPS Continuation: Long-term effects of menopausal hormone therapy on	clinical	Alzheimer's disease	0.950	0.00	recently menopausal women with	proposed	N/A
GWAS of composite biomarker score	exploratory	Alzheimer's disease	0.900	0.00	human patients - East Asian co	proposed	N/A
RBG treatment in ApoE-/- atherosclerosis mouse model	validation	atherosclerosis	0.900	0.00	ApoE-/- mice	proposed	N/A
s:** - Biochemical binding assays measuring PROTAC selectivity for APO	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685]	Litvinchuk A, Suh JH, Guo JL, Lin K, Dav	Neuron	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216]	Banik SM, Pedram K, Wisnovsky S, Ahn G,	Nature	2020	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188]	Cetindag AC, Schipke CG, Esselmann H, Kr	The journal of prevention of A	2026	0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963]	Zhu L, Du L, Wu J, Ding D, Wang J et al.	J Invest Dermatol	2026	0
Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204]	Sang Y, Cao Y, Li S, Quan Y, Wang S et a	Biomaterials	2026	0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196]	Lin Z, Xiong J, Zhang F, Zhang H, Zhu M	Mol Ther	2026	0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227]	Samudra N, Vemuri M, Weitlauf J	Curr Opin Obstet Gynecol	2026	0
Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pa [PMID:41930593]	Yoshida K, Saito N, Takahashi R, Ando S,	J Alzheimers Dis	2026	0
UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylati [PMID:41930933]	Ding SK	Immunol Invest	2026	0
Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disor [PMID:40145985]	Lozupone M, Leccisotti I, Mollica A, Ber	Neural regeneration research	2026	0
Cognitive Decline and Neurodegenerative Markers in Psoriasis: The Role of APOE4 [PMID:41912201]	Sabry HH, Kadhum BQ, Abdulmohsin GN, El-	Dermatology practical & concep	2026	0
Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzhe [PMID:41890452]	Arriaga P, Vianna K, Montez C, Panariell	Cureus	2026	0

Debates (1)

Multi-agent debates referencing this entity

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning GR in their description or question text

Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates

Score: 0.822 · neurodegeneration · 2026-04-05

## Mechanistic Overview Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates Drives Non-Cell-

Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin

Score: 0.807 · biomarkers · 2026-04-22

## Mechanistic Overview Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin starts from the cla

TREM2-mTOR Co-Agonism for Metabolic Reprogramming

Score: 0.803 · neurodegeneration · 2026-04-16

## Mechanistic Overview TREM2-mTOR Co-Agonism for Metabolic Reprogramming starts from the claim that modulating TREM2-mT

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Score: 0.795 · neurodegeneration · 2026-04-02

## Mechanistic Overview Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs) starts from the claim t

Integrated Biomarker Panel for Therapeutic Window Identification

Score: 0.784 · neurodegeneration · 2026-04-15

## Mechanistic Overview Integrated Biomarker Panel for Therapeutic Window Identification starts from the claim that modu

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

Stress-granule RNA-binding protein phase transition across ALS and FTD

Score: 0.780 · multi · 2026-04-28

Shared mechanism across ALS, FTD: Low-complexity RNA-binding proteins normally form reversible stress granules, but ALS/

CX3CR1-TREM2 Integration for Synapse Pruning Normalization

Score: 0.776 · neurodegeneration · 2026-04-16

## Mechanistic Overview CX3CR1-TREM2 Integration for Synapse Pruning Normalization starts from the claim that modulating

Gamma entrainment induces activity-dependent BDNF release to rescue NMJ and dend

Score: 0.773 · alzheimers · 2026-04-28

High-frequency gamma oscillations stimulate activity-dependent release of brain-derived neurotrophic factor (BDNF) from

GRN/progranulin lysosomal insufficiency across FTD, ALS-spectrum stress, and AD

Score: 0.756 · multi · 2026-04-28

Shared mechanism across FTD, ALS, AD: Progranulin insufficiency causes tau-negative, ubiquitin-positive FTD and weakens

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming

Score: 0.748 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The TREM2-CSF1R metabolic cross-talk hypothesis centers on the intricate molecula

H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules

Score: 0.737 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The central molecular mechanism underlying this hypothesis involves the intricate

GR

Understanding Entity Pages

Wiki Pages (20)

RASGRP1 Gene

GRN — Progranulin

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

GRIK3 - Glutamate Receptor Kainate Type Subunit 3

GRIN1 — NMDA Receptor Subunit 1

GRIN2D Protein

GRN Progranulin FTD Causal Chain

GRID1 — Glutamate Ionotropic Receptor Delta Type Subunit 1

GAB2 — GRB2 Associated Binding Protein 2

GRK6 Gene

GRK5 — G Protein-Coupled Receptor Kinase 5

GRK3 — G Protein-Coupled Receptor Kinase 3

GRIN2A Gene

GRIA3 Gene

GRIN2A Protein

GRM1 Gene

GIGYF2 — GRB10 Interacting GYF Protein 2

GRM5 Gene

RASGRF2

CGRP Receptor Modulators in Neurodegeneration