gene

ENO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ENO2 encodes neuron-specific enolase (NSE), a glycolytic enzyme specifically expressed in neurons and neuroendocrine cells. Key biomarker for neuronal injury, Alzheimer's disease, Parkinson's disease, and neuroendocrine tumors.

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🧬 Gene Info

Gene Symbol	ENO2
Full Name	Enolase 2 (Neuron-Specific Enolase)
Chromosome	12p13.31
Protein Type	Enzyme
Function	encodes a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway.
Primary Expression	Neurons, neuroendocrine cells
Molecular Weight	47 kDa
Amino Acids	433 aa
Exons	12
UniProt ID	P09104
NCBI Gene ID	2023
GeneCards	ENO2
Human Protein Atlas	ENO2
Human ENO2	433 amino acids
Mouse Eno2	95% amino acid identity
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ENO2 — AlphaFold P09104 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ENO2 Gene

gene · 2001 words

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Pathway Diagram

graph TD
    ENO2["ENO2"]
    neurodegeneration["neurodegeneration"]
    ENO2 -->|"implicated_in"| neurodegeneration
    style ENO2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ENO2 in their description or question text

No additional research found