Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FANCB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FANCB (Fanconi Anemia Group B): X-chromosomal gene encoding a core complex protein essential for DNA interstrand crosslink repair, Fanconi anemia pathway activation, and implicated in Fanconi anemia, cancer predisposition, and neurodegeneration.
| Gene Symbol | FANCB |
| Full Name | Fanconi Anemia Group B |
| Chromosome | Xq22.3 |
| Protein Family | Fanconi anemia core complex |
| Function | encodes a critical component of the Fanconi anemia (FA) core complex, a multisubunit protein assembly essential for the FA DNA damage response pathway. |
| Molecular Weight | 95 kDa |
| Amino Acids | 859 aa |
| Pathways | pathway: **Core Complex Assembly:** |
| UniProt ID | Q8TD96 |
| NCBI Gene ID | 63027 |
| Ensembl ID | ENSG00000128590 |
| OMIM | 300515 |
| GeneCards | FANCB |
| Human Protein Atlas | FANCB |
| Length | 859 amino acids |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["FANCB"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||