Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FANCM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FANCM (Fanconi Anemia Group M) encodes a DNA translocase essential for interstrand crosslink repair, replication fork remodeling, and genomic stability maintenance, with implications for neurodegeneration through DNA damage accumulation
| Gene Symbol | FANCM |
| Full Name | Fanconi Anemia Group M |
| Chromosome | 7q22.3 |
| Function | encodes a DNA translocase and central initiator of the Fanconi anemia (FA) DNA damage response pathway. |
| Primary Expression | Ubiquitous (high in proliferating tissues, brain, bone marrow) |
| Molecular Weight | ~140 kDa |
| Amino Acids | 1252 aa |
| Exons | 22 |
| UniProt ID | Q8IWA5 |
| NCBI Gene ID | 57697 |
| Ensembl ID | ENSG00000187240 |
| OMIM | 609644 |
| GeneCards | FANCM |
| Human Protein Atlas | FANCM |
| Protein Length | 1252 amino acids |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FANCM["FANCM"]
neurodegeneration["neurodegeneration"]
FANCM -->|"implicated_in"| neurodegeneration
style FANCM fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||