Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FKBP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FKBP4 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with Bipolar. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | FKBP4 |
| Chromosome | 5q35.3 |
| Protein Family | FKBP Family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Cytoplasm, Nucleus |
| Molecular Weight | 51.2 kDa |
| Amino Acids | 459 aa |
| UniProt ID | [Q02790](https://www.uniprot.org/uniprot/Q02790) |
| GeneCards | FKBP4 |
| Human Protein Atlas | FKBP4 |
| FKBP5 | Related immunophilin with higher immunosuppress |
| Associated Diseases | Bipolar |
| Interactions | FKBP5, SKA2 |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FKBP4["<b>FKBP4</b>"]
Bipolar{"Bipolar"}
FKBP4 -->|"associated with"| Bipolar
FKBP5["FKBP5"]
FKBP4 -->|"interacts with"| FKBP5
SKA2["SKA2"]
FKBP4 -->|"activates"| SKA2
GENES["GENES"]
FKBP4 -->|"associated with"| GENES
Cell_Cycle(["Cell Cycle"])
FKBP4 -->|"associated with"| Cell_Cycle
FKBP4 -->|"activates"| FKBP5
Neuron["Neuron"]
FKBP4 -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
FKBP4 -->|"implicated in"| neurodegeneration
SKA2 -->|"interacts with"| FKBP4
FKBP5 -->|"activates"| FKBP4
AND["AND"]
AND -->|"associated with"| FKBP4
GENES -->|"associated with"| FKBP4
style FKBP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||