disease

Bipolar

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Bipolar: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

348Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Bipolar is a disease characterized by neurodegeneration research. Key relationships include: associated with, biomarker for, implicated in. Associated with Als, Alzheimer, Autism. Connected to 152 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	HTR2A, DISC1, FKBP5, NRG1, DAO, BMAL1, GRM4, SYNGR1
KG Connections	327 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Bipolar["Bipolar"] -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    Bipolar["Bipolar"] -->|"associated"| Circadian_Rhythm["Circadian Rhythm"]
    Bipolar["Bipolar"] -->|"therapeutic target"| Akt["Akt"]
    Bipolar["Bipolar"] -->|"therapeutic target"| Pi3K["Pi3K"]
    Bipolar["Bipolar"] -->|"associated"| Epilepsy["Epilepsy"]
    Bipolar["Bipolar"] -->|"associated"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| Bipolar["Bipolar"]
    DAB1["DAB1"] -->|"regulates"| Bipolar["Bipolar"]
    FYN["FYN"] -->|"regulates"| Bipolar["Bipolar"]
    SRC["SRC"] -->|"regulates"| Bipolar["Bipolar"]
    style Bipolar fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (90)

Target	Relation	Type	Str
Schizophrenia	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	implicated_in	disease	0.65
Synaptic Plasticity	regulates	pathway	0.60
Circadian Rhythm	associated_with	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Synaptic Plasticity	implicated_in	pathway	0.60
Blood-Brain Barrier	biomarker_for	pathway	0.60
Microbiota	biomarker_for	pathway	0.60
Oxidative Stress	biomarker_for	pathway	0.60
Mapk	biomarker_for	pathway	0.60
Pyroptosis	biomarker_for	pathway	0.60
Inflammasome	biomarker_for	pathway	0.60
Nf-Κb	biomarker_for	pathway	0.60
Phagocytosis	implicated_in	pathway	0.60
Microbiota	implicated_in	pathway	0.60
Epilepsy	associated_with	disease	0.55
Autism	associated_with	disease	0.55
Ms	associated_with	disease	0.55
Als	associated_with	disease	0.55
Cell Cycle	associated_with	pathway	0.55
Dendritic Spine	regulates	pathway	0.55
Als	biomarker_for	disease	0.55
Inflammation	associated_with	disease	0.55
Inflammation	implicated_in	disease	0.55
Coronary Artery Disease	associated_with	disease	0.55
Depression	biomarker_for	disease	0.55
Parkinson	inhibits	disease	0.55
Diabetes	inhibits	disease	0.55
Depression	inhibits	disease	0.55
Autophagy	activates	pathway	0.55
Oxidative Stress	causes	pathway	0.55
Apoptosis	activates	pathway	0.55
Mitochondrial Function	regulates	pathway	0.55
Circadian Rhythm	regulates	pathway	0.55
Sleep-Wake Cycle	regulates	pathway	0.55
Complement	regulates	pathway	0.55
Glutamate Signaling	expressed_in	pathway	0.55
Neuroinflammatory	associated_with	pathway	0.55
Blood-Brain Barrier	associated_with	pathway	0.55
Angiogenesis	associated_with	pathway	0.55
Synaptic Plasticity	causes	pathway	0.55
Neuron	regulates	cell_type	0.55
Neuron	associated_with	cell_type	0.55
T Cell	regulates	cell_type	0.55
Mitochondrial Function	expressed_in	pathway	0.55
Circadian Rhythm	methylates	pathway	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (258)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	0.75
ALZHEIMER	associated_with	gene	0.75
DEPRESSION	associated_with	gene	0.75
INFLAMMATION	associated_with	gene	0.75
JUN	regulates	gene	0.65
DAB1	regulates	gene	0.65
FYN	regulates	gene	0.65
SRC	regulates	gene	0.65
HTR2A	associated_with	gene	0.65
DISC1	associated_with	gene	0.65
FKBP5	associated_with	gene	0.65
NRG1	associated_with	gene	0.65
DAO	associated_with	gene	0.65
BMAL1	associated_with	gene	0.65
GRM4	associated_with	gene	0.65
SYNGR1	associated_with	gene	0.65
BDNF	associated_with	gene	0.65
NCAM1	associated_with	gene	0.65
RGS4	associated_with	gene	0.65
GRIN2B	associated_with	gene	0.65
DRD1	associated_with	gene	0.65
TPH2	associated_with	gene	0.65
GABRA5	associated_with	gene	0.65
POLG	associated_with	gene	0.65
TRPM2	associated_with	gene	0.65
GRM3	associated_with	gene	0.65
HTTLPR	associated_with	gene	0.65
MITOCHONDRIAL DNA	associated_with	gene	0.65
PERIOD3	associated_with	gene	0.65
G72	associated_with	gene	0.65
GENES	associated_with	gene	0.65
PDLIM5	expressed_in	gene	0.65
MTDNA	expressed_in	gene	0.65
DNA	expressed_in	gene	0.65
SKA2	associated_with	gene	0.65
ANK3	inhibits	gene	0.65
PI3K	therapeutic_target	gene	0.65
AKT	therapeutic_target	gene	0.65
EZH2	therapeutic_target	gene	0.65
PI3K	associated_with	gene	0.65
AKT	associated_with	gene	0.65
AMPK	activates	gene	0.65
AKT	activates	gene	0.65
ALZHEIMER'S DISEASE	protects_against	gene	0.65
ALS	protects_against	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	protects_against	gene	0.65
INFLAMMATION	protects_against	gene	0.65
GUT-BRAIN AXIS	therapeutic_target	gene	0.65
INFLAMMATION	therapeutic_target	gene	0.65
NEUROINFLAMMATION	therapeutic_target	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Bipolar

Understanding Entity Pages

Summary

Wiki Pages (21)

Bipolar Cells in Visual Processing

Clinical Management Guide for CBS/PSP

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD)

CNTN5 — Contactin 5

Mitophagy Pathway in Neurodegeneration

gabaergic-dysfunction

Lithium for PSP/CBS — Phase 2 Trial

lithium-tauopathy

MACF1 — Microtubule-actin crosslinking factor 1

mitophagy-defect

Multiple Sclerosis (MS)

Rotigotine and Rivastigmine Combination Therapy for Alzheimer's Disease (NCT06702124)

Visual Pathway Circuit

Allen Human Brain Atlas

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

A 52-Week, Open-Label Extension Study of ACP-204 in Adults With Alzheimer's D... (NCT06194799)

Johnson & Johnson